Flashcards
Invasive Breast Cancer Adjuvant Therapy
Flashcards do conjunto (19)
- 1Adjuvant drug for Stage 1A Cancer ER(+), PR(+)Endocrine therapy
- 2Adjuvant drug for Stage 1A Cancer ER(-), PR(-)+/- Chemotherapy
- 3Adjuvant drug for Stage IB - III Cancer ER(+), PR(+), HER2(+)Chemotherapy + Trastuzumab + Endocrine therapy +/- pan-EGFR
- 4Adjuvant drug for Stage IB - III Cancer ER(+), PR(+), HER2(-)Chemotherapy + Endocrine therapy
- 5Adjuvant drug for Stage IB - III Cancer ER(-), PR(-), HER2(+)Chemotherapy + Trastuzumab +/- pan-EGFR
- 6Adjuvant drug for Stage IB - III Cancer ER(-), PR(-), HER2(-)Chemotherapy
- 7Adjuvant drug for IV Cancer ER(+), PR(+), HER2(+)Chemotherapy + Trastuzumab/Lapatinib + Endocrine therapy
- 8Adjuvant drug for IV Cancer ER(+), PR(+), HER2(-)Chemotherapy + Endocrine therapy +/- CDK4/6 inhibitor
- 9Adjuvant drug for IV Cancer ER(-), PR(-), HER2(+)Chemotherapy + Trastuzumab/lapatinib
- 10Adjuvant drug for IV Cancer ER(-), PR(-), HER2(-)Chemotherapy
- 11Premenopausal women with hormone receptor–positive [ER (+), PR(+)] tumors, treat w/ ....tamoxifen for 5 to 10 years
- 12Women who are known to be in menopause at any age, and who have hormone receptor–positive [ER (+), PR (+)] tumors, treat w/ ...1. initial trt = 5 yrs of aromatase inhibitors (AIs) +/- tamoxifen
2. AIs are known to increase PFS (not OS) - 13If a woman on tamoxifen becomes post-menopausal within 5 years of starting tamoxifen (either naturally or due to oopherectomy), what do you do?switch from tamoxifen to an aromatase
inhibitor - 14Preferred Single Agents for stage IV chemotherapy (Anthracyclines)1. Doxorubicin
2. Epirubicin
3. Pegylated liposomal doxorubicin - 15Preferred Single Agents for stage IV chemotherapy (Taxanes)1. Paclitaxel +/- Bevacizumab
2. Docetaxel
3. Albumin-bound paclitaxel - 16Preferred Single Agents for stage IV chemotherapy (Antimetabolites)1. Gemcitabine
2. Capecitabine - 17Preferred Single Agents for stage IV chemotherapy (Microtubule inhibitors)1. Vinorelbine
2. Eribulin
3. Ixabepilone (taxane & anthracycline failures) - 18Preferred Combination Regimens for stage IV chemotherapy (1)1. cyclophosphamide/doxorubicin/fluorouracil (CAF/FAC)
2. fluorouracil/epirubicin/cyclophosphamide (FEC or CEF)
3. doxorubicin/cyclophosphamide (AC or CA)
4. epirubicin/cyclophosphamide (EC or CE) - 19Preferred Combination Regimens for stage IV chemotherapy (2)1. doxorubicin/docetaxel or doxorubicin/paclitaxel (AT)
2. cyclophosphamide/methotrexate/fluorouril (CMF)
3. gemcitabine/paclitaxel (GT)
4. docetaxel/capecitabine