Flashcards
TLRs
Flashcards do conjunto (11)
- 1TLR1:TLR2 heterodimerLipopeptides
GPI - 2TLR2:TLR6 heterodimerLipoteichoic acid
Zymosan - 3TLR3double stranded viral RNA
found on NK cells - 4TLR4 homodimerLipopolysaccharide
- 5TLR5Flagellin
- 6TLR7Single stranded viral RNA
- 7TLR8Single stranded viral RNA
found on NK cells - 8TLR9Unmethylated CpG-rich DNA
- 9TLR10 homodimer and heterodimer with TLR1 and 2Unknown
- 10What are TLRs?Non-opsonic, non-phagocytic receptors that sense pathogens and trigger inflammatory signalling pathways leading to inflammatory cytokine production
- 11LPS recognition and signallingA complex of TLR4, MD2, CD14 and LPS is assembled at the macrophage surface
MyD88 binds TLR4 and activates IRAK4 to phosphorylate TRAF6, which leads to phosphorylation of IKK
IKK phosphorylates IkB, leading to its degradation and release of NFkB, which enters the nucleus
NFkB activates transcription of genes of inflammatory cytokines, which are synthesised in cytoplasm and secreted via ER
Informações
- Descrição
- FHS Part I Immunology and Microbiology FlashCards sobre TLRs, criado por Eleanor Smith em 17-09-2020.
- Criado por
- Eleanor Smith
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