Flashcards
Antibody Structure and Function
Flashcards do conjunto (15)
- 1where are AB's effective?tissue fluid
- 2describe the structure of an antibodycomposed of glycoproteins, 2 heavy and 2 light chains linked by disulphide bonds
- 3describe the constant and variable regions of the moleculeheavy chain is made up of constant region and variable portion at end, which together with end portion of light chain, makes up the antigen binding site
- 4what are the 3 main functions of antibodies?neutralisation, opsonisation and complement activation
- 5name the 5 isotypesIgD,IgM,IgG,IgA,IgE
- 6which part of the antibody is different within classes and between classes?within: variable region (VDJ recombination)
between: heavy chain constant - 7how does a B cell class switch?alters which heavy chain gene is used
- 8where is IgD found and what is its function?on surface of naive B lymphocytes and acts an as antigen receptor
- 9what is the role of IgM?activates complement, good first line of defence
- 10why is IgG such a good antibody?can neutralise, activate complement and important for opsonisation
- 11which is the only antibody to cross the placenta?IgG
- 12where is IgA found?in secretions such as saliva, tears, bronchial secretions, nasal mucosa
- 13which of the 3 functions is carried out by IgA?neutralisation
- 14which cells have a receptor for IgE?mast cells and eosinophils
- 15what does IgE trigger in response to parasites or allergic disease?degranulation of mast cells
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- (LYM) FlashCards sobre Antibody Structure and Function, criado por becki_fernandes em 02-05-2013.
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