Fluxograma
Sem título
Conteúdo do fluxograma
Prolactin binds to dopamine neurons in hypothalams
JAK2 activated by phosphorylation
Cytosolic tails phosphorylated
STAT5 phosphorylated
STAT5 dimerizes and enters nucleus
STAT5 induces production of tyrosine hydroxylase
Tyrosine hydroxylase makes dopamine
Lactation increases prolactin production
Hyperprolactinemia
High levels of prolactin in blood
Lactation
Suckling upregulates CIS
CIS prevents dimerisation of STAT5
No STAT5 dimer goes to nucleus
No STAT5 induce the production of tyrosine hydroxylase
Dopamine is not secreted by the dopamine neurons in hypothalamus
Dopamine does not bind to dopamine receptor of lactotroph cells
Lactotroph cells produce more prolactin
Prolactin induces more milk synthesis and secretion
Suckling
Stimulates the nipple more
Hypothalamus stimulated more
Posterior pituitary stimulated more
Suckling
Nipple stimulated more
Hypothalamus stimulated more
Posterior pituitary stimulated more
More oxytocin secreted
Myoepithelial cells contract
Milk ejection
Less dopamine (prolactin inhibitor)
More prolactin releasing hormone
Lactotroph cells secrete more prolactin
Prolactin stimulates epithelial cells
More milk synthesized and secreted
Informações
- Descrição
- Fluxograma sobre Sem título, criado por Nathan Lin em 09-06-2018.
- Criado por
- Nathan Lin
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