Lymph Nodes DSM

LYMPH NODES

Lymphoid lobule

Associated cells: Cells T and B, APCS, FDCS, inflammatory mediators

Reticular Meshwork

Associated cells: Lymphocytes, ADC, bacterias, macrophages, reticular fibers

Cords

Associated cells: Histiocytes and lymphocites

Parenchyma (lymphocytes)

Associated cells: Lymphocites, lymphoid parenchymal cells

High Endothelial Venules

Associated cells: Remote inflammatory, activity MCP-1 and IL-8, endothelial venules cells

Paracortical Sinuses

Associated cells: Lymphocites, endothelial cells, STP

Dendritic Cells

Associated cells: Lymphocites, T cells

Follicular Dendictic cells

Associated cells: B cells and reticular cells

Dina Sánchez Molina

Contains specific lobular structures so changes in these compartments reflect alterations in the lobules.

Give space to the APC and lymphocytes for mix and move

Dominate the histological appearence of lymphocites and obscure the reticular meshwork.

Helps to destroy antigens on the blood and lymph

Gateways intravascular lymphocytes use to immigrate into the reticular meshwork from the closed circulation.

APC that presents antigen B. They trap antigen-antibody complexes through their complement and FC receptors and retain these immune complexes on their cell membranes for more tha a year.

Potent APCs that collect and process antigens from tissues, carry them to lymph nodes and present them to T cells to initiate primary immune responses.

Originates as blind end cul de sacs in the interfollicular cortex, run through the peripheral DCU and discharge into the medullary sinuses.