13391953
Descrição
Mapa Mental por Usuário eliminado, atualizado more than 1 year ago
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Criado por Olivia McRitchie
aproximadamente 6 anos atrás
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Copiado por Olivia McRitchie
aproximadamente 6 anos atrás
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Drugs of the Parasympathetic NS
- Cholinergics/Parasympathomimetics: Stimulate the parasympathetic NS
- Rest and digest response
- Direct acting: Bind to cholinergic
receptors to produce rest and
digest resposne
- Relatively resistent to
achetylcholenesterase, so
they last longer than Ach
- Poorly absorbed in Gi
tract, do not cross
blood-brain barrier
- Also called
muscarinic agonists
- Relatively resistent to
achetylcholenesterase, so
they last longer than Ach
- Indirect acting: Inhibit action of
AchE, allowing endogenous Ach to
avoid rapid destruction and bind
with cholinergic receptors for
longer
- Also called
cholinesterase
inhibitors
- Affects a lot more sites.
- Also called
cholinesterase
inhibitors
- Very few of these are widely used because of high potential for serious adverse effects
- Some are used for affect on skeletal muscle (see pg. 135)
- Can cause a cholinergic crisis
- Some are used for affect on skeletal muscle (see pg. 135)
- Rest and digest response
- Cholinergic blocking/Anticholinergics: Inhibits the parasympathetic nervous systm
- Fight or flight respose
- Called muscarinic antagonists b/c they're selective for Ach muscarinic receptors
- Competes with Ach for binding with muscarinic receptors,
- Causes sympathetic NS actions to dominate
- Causes sympathetic NS actions to dominate
- Relatively high incidence of side effects
- Fight or flight respose
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