gout

gout

1. types of arthritis

2. why

   • deposition of monosodium urate crystals in joint

3. risk factors

   • ifestyle modifications
   • medical conditions
   • certain medications
   • family history
   • age and sex

4. pathogenesis

   • phagocytosis by monoxytes
     • il1
     • il6
     • tnf
     • il8
   • neutrophil chemotaxis
     • lt
     • prostaglandins

5. classifications

   • primary
     • diet
     • enzyme
   • secondary
     • renal failure
     • malignancy
     • inborn errors of metabolism
   • vs pseudogout

6. investigations

   • cbc
   • uric acid
   • bmp
   • synovial fluid analysis
   • urine
   • rheumatoid factor
     • ana
     • rf
   • non lab
     • xrays
     • ultrasound
     • ct scan
     • mri

7. management

   • allopourinol
     • xanthine oxidase inhibitor
   • probenecid
     • increase uric acid excretion
   • colchicine
     • inhibit leukocyte entry
   • nsaids
     • pain relief
   • acute
     • nsaids
     • sterids
     • olchicine
   • prophylaxis
     • provenecid
     • allpopurinol

8. prevention

   • diet
   • dialysis
   • reduce meat
   • reduce fish
   • reduce wine

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