305451
TUMOR SUPPRESSORS
- SIGNALING
- TGF-B PATHWAY
- p-15
- INHIBIT CYCLIN D-CDK4,6
- INHIBIT CYCLIN D-CDK4,6
- PAI-1
- INHIBIT MMP'S
- INHIBIT MMP'S
- p-15
- TGF-B PATHWAY
- CELL CYCLE INHIBITORS
- LOSS OF Rb PROTEIN
- E2F- ON
- E2F- ON
- LOSS OF Rb PROTEIN
- CDK INHIBITORS
- p21 CIP FAMILY
- universal inhibitors
- p53 INDUCED
- universal inhibitors
- INK4 FAMILY
- p15
- p16
- MELANOMA
- MELANOMA
- SPECIFIC: CYCLIN D-CDK4,6
- p15
- LOSS OF p53
- CAN'T ARREST CELL
CYCLE PROGRESSION
- CAN'T INDUCE DNA
REPAIR ENZYMES
- CAN'T INDUCE APOPTOSIS
- CAN'T ARREST CELL
CYCLE PROGRESSION
- BRCA-1
- ENHANCE p53
- ENHANCE p21
- ENHANCE p21
- Wee1 Kinase +
CDC25
phosphatase
- ENHANCE p53
- p21 CIP FAMILY
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