309797
Descrição
Mapa Mental por kathrynmoar, atualizado more than 1 year ago
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Criado por kathrynmoar
mais de 10 anos atrás
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Competitive and
Noncompetitive Inhibitors
- Competitive Inhibitors
- mimic the substrate and compete for the
binding to the active site
- effectiveness = depends on affinities for that site.
- Km is increased in a double reciprocal plot
- mimic the substrate and compete for the
binding to the active site
- Noncompetitive Inhibitors
- bind at a site other than the active one which
means no competition with the substrate
- Example: covalent modififcation -
the action of aspirin in acylating
cyclooxygenase at a serine at the
active site
- Uncompetitive inhibition
- inhibitor binds to the ES complex only
- inhibitor binds to the ES complex only
- bind at a site other than the active one which
means no competition with the substrate
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