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1. Granulocytes have granules in the cytoplasm and the varying shapes of nucleus,which is lobed into three segments.

   • Neutrophils
     • 2 types of granules: Primary contains cationic proteins & defensins to kill bacteria, lysozyme to break down bacterial cell wall. The secondary granules form toxic oxygen compounds & lactoferrin to take iron from bacteria.
       • Invading microbes & damaged tissue release LPS & Interleukin-1
         • Causes endothelial cells to release ICAM-1 & receptors of neutrophil bind to this
           • Neutrophil starts to move from the circulatory system into the tissue (diapedesis).
             • At the inflammatory cite- neutrophil enclose the particle with pseudopodia, cytotoxic chemicals & enzymes to destroy it
               • Apoptosis- neutrophils go through programmed cell death. Ingested by macrophages to ensure its toxic contents are disposed safely
   • Eosinophils
     • They have a kidney-shaped lobed nuclei and the granules contain toxic protein & cationic protein
       • They kill parasites & respond to allergic disease by releasing inflammatory mediators