4417653
Anatomy and Histology of salivary glands
- Type of acini (p = serous, smg
= all three >80% serous, slg =
mostly mucous)
- Serous
- Extensive RER, Golgi and
secretory granules
(amylase, lysozyme)
- Many basal
invaginations (as
more continuous)
- Lots of
junctional
complexes
- Extensive RER, Golgi and
secretory granules
(amylase, lysozyme)
- Mucous
- Fewer basal invaginations compared to
serous - less "basal" level of secretion
- Secrete mucin glycoprotein -
less enzymatic secretions
more carbohydrate
- More prominent Golgi
than serous, less
extensive RER + mito
- Fewer basal invaginations compared to
serous - less "basal" level of secretion
- Mixed
- Serous "sit" on top of mucous cells
- Serous "sit" on top of mucous cells
- Myoepithelial cells surround
acinus - joined to acinus by
DESMOSOMES - squeeze acini
to increase salivary flow
- Serous
- Developmental origin
- ECTODERMALLY derived from
stomatodeum lining
- Oral epithelial cells proliferate
into surrounding
ectomesenchyme and form
buds with epithelial cords to OE
surface
- 4-6-8-12 weeks pattern formation
(largest to smallest glands)
- Surrounding condensed
mesenchyme induces
differentiation of oral
epithelial invaginated tissue
- Surrounding condensed mesenchyme
becomes fibrous capsule - lymph nodes
frequently become trapped because
this condensation is delayed
- Duct system forms from
epithelial cords - further
branching for different
duct types
- Epithelial
parenchymal tissue
forms the lobules
- ECTODERMALLY derived from
stomatodeum lining
- Duct system - Acinus - intercalated - striated - excretory (terminal)
- Intercalated (INTRAlobular)
- Smallest duct
- Simple cuboidal epithelium
- Secretory proteins such
as lysozyme
- Smallest duct
- Striated (INTRAlobular)
- Striated due to high infolded
basolateral membrane containing
elongated mitochondria
- Modification of saliva
occurs here
- Columnar cells
- Striated due to high infolded
basolateral membrane containing
elongated mitochondria
- Excretory (terminal - INTERlobular)
- End part of the duct system
- Pseudostratified
columnar epithelium
- Embeddded in
connective tissue
between the lobules
- End part of the duct system
- Interlobular = in septal connective
tissue outside paremchyma,
Intralobular = inside paremchyma
- Intercalated (INTRAlobular)
- Age changes
- Stroma becomes fibrotic and
accumulates lymphocytes
- More fat cells in parotid
- Linked to xerostomia / sjogrens
- Stroma becomes fibrotic and
accumulates lymphocytes
- Minor glands
- 8-10% of all saliva
production
- Palatal, lingual, labial,
buccal, retromolar
location
- None in gingiva +
anterior palate
- 8-10% of all saliva
production
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