517506
Descrição
Mapa Mental por v.djabatey, atualizado more than 1 year ago
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Criado por v.djabatey
aproximadamente 10 anos atrás
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retinoblastoma
- malignant tumour of retinal cells
- rare
- but = 5% of severe renal impairment in kids
- but = 5% of severe renal impairment in kids
- an affect one or both eyes
- all bilat tumours (& 20% of unilat) are hereditary
- susceptibility gene
- chromosome 13
- chromosome 13
- dominantly
inherited,
but
incomplete
penetrance
- most cases
present 0-3
years old
- kids from families w/ hereditary form
- regular screening from birth
- regular screening from birth
- clinical features
- white pupillary reflex
- commonest presentation
- commonest presentation
- squint
- white pupillary reflex
- Ix
- under anaesthetic
- MRI
- examination
- MRI
- NO BIOPSY
- under anaesthetic
- Rx
- aim to cure
but preserve
vision
- Rx based on
ophthalmological
findings
- enucleation of eye
- for more advanced disease
- for more advanced disease
- chemo
- in bilat disease
- shrink tumour
- fb local laser Rx to retina
- in bilat disease
- radiotherapy
- mostly for Rx of recurrence
- can be used in adv disease
- mostly for Rx of recurrence
- aim to cure
but preserve
vision
- tumours often multifocal
- most are cured but many visually impaired
- sig risk of 2nd malignancy esp sarcoma among
hereditary retinoblastoma survivors
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