Membrane Proteins & Signalling

Membrane Proteins & Signalling

1. Transport

   • Active Transport
     • P-Class
       • Muscle Ca+ ATPase
       • Na+/K+ ATPase
     • V-Class
     • F-Class
     • ABC
     • Secondary Active
       • Na+/Glucose Symporter
   • Facilitated Diffusion
     • GLUT2
     • K+ Resting Channel
   • Passive Diffusion

2. Intracellular Receptors

   • Steroid Binding Receptor
     • Glucocortucoid Receptor
       • Inhibitor Proteins

3. Cell-Surface Receptors

   • GPCR
     • Trimeric G Protein
     • Epinephrine
       • Gai/Gas
         • Adenylyl Cyclase
           • cAMP
             • CFTR
             • PKA
               • Catalytic Subunit
                 • CREB
                   • CRE, CBP/P300
               • GPK
                 • GP
               • GS
               • PP
         • Pertussis Toxin
         • Cholera Toxin
     • Acetylcholine
       • GBy
         • K+ Channel (heart)
       • Gaq, Gao
         • PLC
           • PIP2
             • DAG
             • IP3
               • Ca+ Channel
                 • Cytosolic Ca+
                   • PKC
                   • Calmodulin
                     • NO Synthase
                       • NO
                         • Guanylate Cyclase
                           • cGMP
                             • PKG
                             • PDE (-)
                               • Viagara
   • RTK
     • SH2/PTB
       • Src-c/Src-v
       • IRS-1
     • EGF
       • EGFR
         • GRB2
           • Sos
             • Ras
               • Raf, 14-3-3
                 • MEK
                   • MAPK
       • HERs
         • HER2
         • Herceptin

4. Intercellular Signalling

   • Paracrine
   • Autocrine
   • Endocrine
   • PM-Attached Proteins

5. Functional Expression Assay

6. Apoptosis

   • Intrinsic
     • Loss of Trophic Factor Signal
       • No activation of PKB
         • No phosphorylation of Bad
           • Bcl-2
     • DNA damage
       • p53
         • PUMA
           • BCl2
             • Bak/Bax
               • Cytochrome C
                 • Apaf-1
                   • Caspase-9
                     • Caspase-3
   • Extrinsic
     • Fas
       • Fas reeceptor
         • FADD
           • Caspase-8
             • Effector Caspases
             • BID
               • tBID
                 • Bcl-2
   • Executionner Caspase
   • Inhibitor Caspase