Inflammatory cytokines

Inflammatory cytokines

1. IL6, IL-beta, TNG-alpha

   • Released / produced by macrophages
     • Act on
       • Dendritic cells
         • Stimulate maturation of these cells
           • Adaptive immune response
       • Liver
         • Acute- phase proteins
       • Fat and muscle
         • Energy and protein mobilisation
           • Increase body temperature
             • Decrease viral and bacterial replication
               • Increase antigen processing
                 • Increase adaptive immune response
       • Hypothalamus
         • Increase body temperature
           • Decreases viral and bacterial replication
           • Increases antigen presentation to T cells
             • Stimulates adaptive immune response
       • Bone marrow
         • Neutrophil mobilisation