cholinergic receptors

cholinergic receptors

1. Muscarinic

   • 5
     • M1
       • gastric gland, CNS, autonomic ganglia
       • IP3/DAG
     • M2
       • heart
       • cAMP, k+channels
     • M3
       • smooth muscle, exocrine glands, endothelial cells
       • IP3/DAG
     • M4
       • M5
     • M5
       • CNS
   • acts via 2nd messsengers, g-protein coupled receptors

2. Nicotinic

   • 2
     • NM
       • NMJ
     • NN
       • CNS, autonomic ganglia, adrenal medula
   • acts by opening ion channels thereby depolarising