Coagulation

Coagulation

1. Intrinsic pathway

   • Colagen
     • Factor XII
       • Factor XIIa
         • Factor XI
           • Factor XIa
             • Factor IX
               • Factor XIa
                 • Factor X
                   • Factor Xa
                     • Prothrombin (II)
                       • Thrombin (IIa)
                         • Fibrinogen (I)
                           • Fibrin (I)
                             • Factor XIII
                               • Factor XIIIa
                             • Stable finrin clot
                         • • Activation AT-III
                         • Direct Thrombin Inhibitors
                           • Bivalirudin
                           • Argatroban
                           • Babigatran
                         • Low molecular weight heparins
                           • Activation AT-III
                             • Fondaparinux
                             • Enoxaparin
                             • Dalteparin
                     • Heparin

2. Extrinsic pathway

   • Factor III
     • Factor VII
       • Factor VIIa