Flashcards
Week 11 Complementary therapies, drug toxicology, monitoring drug toxicology
Flashcards do conjunto (20)
- 1Complementary/ alternative medicines (CAM)Wide range of therapies and procedures
comp: used with standard medical treatments
alt: used instead of standard medical therapy - 2CAM facts50% of australians use them
particularly patients with chronic diseases: cancer, arthritis, chronic pain, AIDS, GI probelms - 3CAM Herbals/ vitaminsst johns wort, selenium for AIDS, vitamins used most
- 4Pregnancy/labourraspberry leaf, ginger
- 5UTIScranberry juice, BUT interaction with warfarin
- 6COLDS/FLUechinacea, BUT allergic reactions possible
- 7DepressionSt john's wort, BUT drug interactions with SSRIS = SERTONIN SYNDROME
- 8Issues with CAM aes:hepatoxicity, nephrotoxicity, strokes.
contain contaminants (heavy metals, toxins, drug contaminants) - 9Issues with CAMPatients do not inform health professional they are using CAM "Viewed as healthy"
- 10Therapeutic goods administrationinternational sale not regulated, some medicine exempt
- 11Where drugs produce toxicityall organs of body,
particularly in liver, blood, kidney (altered perfusion/function)
gut (ulcers)
all are exposed to drug or conc of drug as part of metabolism or excretion - 12Drug induced liver injury1. intrinsic hepatotoxins: predictable, dose-related toxicity paracetomol
2. hypersensitivity: hepatotoxins e.g. halothane, unpredictablem dose-unrelated, rare
3. cholestatic hepatotoxicants: e.g. ethanol: cessation of bile flow/formation = jaundice - 13Adverse drug reactionsnoxious and unintended drug response which occurs at therapeutic doses
- 14Type A ADRSaugmented, over- extension of drugs intended action, common, usually predicatable and reversible e.g. postural hypotension with antihypertensives
- 15Type B ADRS:Bizzare, uncommon, usually unpredicatble and not dose related, often severe with high morbidity/mortality e.g. penicillin anaphylaxis
- 16ADRs exponentiallyincrease with more than 4 concurrent medications (drug interactions)
- 17ADRScan be due to drug interactions, diet, CAM interations
PK related / PD related - 18Examples of ADRS from interactionsPK: viagra and grapefruit juice or terfenadine and antifungals 'azoles'
PD: angina drugs (nitrates) and viagra
Complementary medicines and drugs: St John's wort and anti-coagulants (PK-related therapeutic failure) or SSRIs (Serotonin syndrome) - 19General approach to deliberate self poisoningresus
risk assessment
decontamination
screening tests
enhanced elimination
antidotes
supportive care and disposition - 20Risk assessmentmost important step to early management of poisoning
takes in acc
age
co morbidities
agent(s)
dose (s)
time since ingestion
symptom progression since ingestion
physical examination
screening tests (BSL, ABG, ECG, Paracetamol, Local tox epidemiology)
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- O usuário eliminou as informações de disciplina FlashCards sobre Week 11 Complementary therapies, drug toxicology, monitoring drug toxicology, criado por Usuário eliminado em 16-10-2017.
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- Usuário eliminado · out 2017
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- 16 out 2017
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- Criado por Elizabeth Then · 16 out 2017
- Copiado por Elizabeth Then · 16 out 2017
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