Endochondral Ossification :)

Endochondral Ossification

1. 1. Differentiation of Embryonic Mesoderm

   • Mesenchymal Progenitor Cells
     • Mesenchymal Cells
       • 2. Become Chondroblasts
         • 3a. Produce Hyaline Cartilage Skeleton for ex) Long Bone
           • 3b. Middle of the Diaphysis= Primary Ossification Center
             • 4. Calcification of the Primary Ossification Center begins occuring
               • 5. Vascularization: Periosteal Bud
                 • Bring in Osteoblasts
                   • Build Up Bone Matrix
                     • Become Osteocytes
                       • Hyaline Cartilage disintegrates
                 • Bring in Nutrients
                 • Eliminate wastes of growing bone cells