11645260
Questão 1
Questão
Main clinical cognitive features of Huntington’s disease include the following except:
Responda
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B. Memory difficulties
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A. Mental slowing
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C. Language severe problems
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D. Language well preserved
Questão 2
Questão
Question 2
Characteristics in Early stages of Huntington’s disease:
(multiple answers possible)
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A. Chorea
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B. Agitated /mood swings
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C. Distractable
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D. Demented
Questão 3
Questão
Characteristics in Late stages of Huntington’s disease except: (multiple answers possible)
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B. Dystonia/bradykinetic
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C. Mood swings
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D. Demented
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A. Abulic
Questão 4
Questão
Question 7
The gene related to Huntington’s disease is Huntingtin (htt) and in order to become pathogenic it should have:
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B. >36 insertions
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C. >36 deletions
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D. >36 GAC repeats
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A. >36 CAG repeats
Questão 5
Questão
Main clinical psychiatric features of Huntington’s disease include:
(multiple answers possible)
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A. Irritability
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B. Stable mood
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D. Compulsive behaviour
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C. Social withdrawal
Questão 6
Questão
The brain structures which are mainly affected by Huntington’s disease are:
(multiple answers possible)
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A. Sustantia Nigra
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B. Cerebral cortex
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C. Hippocampus
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D. Striatum
Questão 7
Questão
Main clinical motor features of Huntington’s disease include:
(multiple answers possible)
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A. Chorea
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B. Evolution from hyperkinetic to hypokinetic
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C. Evolution from hypokinetic to hyperkinetic
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D. Gait abnormalities
Questão 8
Questão
Question 8
Other features frequently found in patients with Huntington’s disease are the following except:
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A. Metabolic abnormalities
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B. Weight gain
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C. Circadian rhythm disturbances
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D. Autonomic abnormalities
Questão 9
Questão
Question 9
Huntington’s disease is an inherited disorder, it is a _____ condition.
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Aut Dom
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Aut Rec
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X Dom
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X Rec
Questão 10
Questão
Question 10
Mutated Huntingtin lead to:
(multiple answers possible)
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A. Transcription interference
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B. Formation of inclusions
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C. Cellular dysfunction
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D. Cell death
Questão 11
Questão
The gene defect Huntington’s disease is known to be on Chromosome
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2
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4
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9
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11
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