Quiz
Previous year Quizz 5
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Perguntas do quiz (19)
1Which of the following answers is correct?
- AThe NOAEL is defined as the highest dose at which no clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies
- BThe NOAEL is defined as the lowest dose at which at least one clinical and/or biological relevant adverse effect is observed in preclinical toxicology studies
2The following are true about the early stages of schizophrenia: (more than one answer might be correct)
- AAttention deficits may be present
- BMotor dysfunction is an early warning sign.
- CMedical interventions prior to the first psychotic symptoms may be more effective
- DBrain structure that is clearly different from healthy individuals
- EMild or moderate disturbance in language.
3Schizophrenia is a genetic disorder,
- Abut it is not heritable
- Band its heritability is around 80%.
- Cand environmental factors are not important.
- Dand its heritability is around 10%.
- Ebut genetics factors are not associated with schizophrenia symptoms
4What types of bias affect the "internal validity" of a study? (several answers are correct)
- Aselection bias (creating groups with different confounders; solved by randomization)
- Bperformance bias and detection bias (investigators respectively treating or assessing more positively those subjects on the treatment arm; controlled by blinding interventions and outcome assessments)
- Cattrition bias (dropout of subjects with a negative outcome not included in the final result)
5Which brain function is dominated most by one hemisphere?
- AHearing
- BSmelling
- CLanguage
- DMemory
- EVision
6Which of these anatomic structures is not part of the basal ganglia?
- ACorpus striatum
- BRed nucleus
- CSubthalamic nucleus
- DCaudate nucleus
7A meta-analysis is a study that
- Aretrospectively combines all trials performed by one group
- Beliminates the bias introduced by studies of low quality
- Ccan only be performed when more than 10 trials have been performed
- Dis a prospective trial of study quality
- Enone of the above
8Which study(ies) belong(s) to Phase I? (more than one answer might be correct
- ABioequivalence
- BFirst in Human
- CPharmacokinetics in renal impairment
- DProof of concept
- EPharmacokinetic drug interaction
9What has the neurotransmitter dopamine been shown to encode?
- Astop signals
- Breward signals
- Cfear signals
- Dmotor signals
10Which answer is incorrect? Risk factors for schizophrenia include:
- AWeight gain
- BInfluenza infection during pregnancy
- CToxoplasmosis gondii
- DAge of father at conception
- EHigh expressed emotions families
11What is the main advantage of bipolar electrophysiological recordings, compared to a common reference?
- Abetter spectral resolution
- Bbetter time resolution
- Cbetter spatial resolution
- Dhigher amplification
12Which of the following statements is correct?
- AA SUE is always related to the administration of the test substance
- BA SUSAR can be a serious or a non-serious adverse reaction
- CA SUSAR should be reported to Ethic Committee and Health Authorities
13The attrition (=failure) rate from first in man to registration of a drug in medicine is typically ...
- A50%
- B90%
- C20 %
- D30%
- EE. 99%
14What are the legal preconditions for the conduct of a clinical study? (more than one answer is correct)
- AIRB approval
- BInsurance Certificate
- CData protection approval
- DYouth welfare office approval
- EStudy bank account
15Which of the following statements is correct?
- AThe first dose in humans is equivalent to NOAEL
- BThe first dose in humans is a fraction of NOAEL
- CThe first dose in humans is higher than NOAEL
16Ownership of intellectual property in academic research in Germany and the US is held by
- Athe inventor(s)
- Bthe funding agency
- Cthe University
- DResearcher(s) who are not employed by the University but inventor(s)
- Ethe University
Researcher(s) who are not employed by the University but inventor(s)
17Which of the following statements is true regarding the striatum? (more than one answer is correct)
- Areceives inhibitory input from the cortex
- Bconsists of the lenticular nucleus and the putamen
- Creceives dopaminergic input from the substantia nigra pars compacta
- Dcontains cells that use acetylcholine as their transmitter
- Eall of the above statements are true
18Which other description of the clinical symptom chorea is correct?
- ABabinski sign
- Bakinesia
- Crigidity
- Duncontrollable involuntary movement
- Espasticity
19The primary outcome of a First-in-Human study is always:
- ASafety and tolerability
- BFeasibility
- CPharmacodynamics
- DTherapeutic effect
Informações
- Descrição
- Quiz sobre Previous year Quizz 5, criado por Alba Del Rio Serrato em 03-12-2017.
- Autor
- Alba Del Rio Serrato
- Idioma
- English
- Visualizações
- 33
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