13119854
Descrição
Quiz por Alannah McDonnell, atualizado more than 1 year ago
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Criado por Alannah McDonnell
aproximadamente 6 anos atrás
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Questão 1
Questão
What is normal GFR in adult humans?
Responda
-
100-125 ml/min
-
4500-6000 ml/min
-
1 - 2 ml/min
-
540 - 900 ml / min
Questão 2
Questão
What does glomerular ultra-filtrate consist of?
Responda
-
water
-
small solutes
-
large solutes
-
plasma
-
urine
Questão 3
Questão
Glomerular Ultrafiltrate is normally ...
Responda
-
containing proteins
-
protein free
Questão 4
Questão
What does Regulated reabsorption of water and solutes allow for?
Responda
-
regulation of extracellular fluid volume
-
regulation of osmolality
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regulation of acid base balance
-
homeostasis of whole body phosphate concentrations
-
homeostasis of whole body calcium concentrations
-
homeostasis of whole body potassium concentrations
Questão 5
Questão
Which of these are freely filtered but not reabsorbed?
Responda
-
urea
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creatinine
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water
-
salt
-
proteins
Questão 6
Questão
Permselectivity = the restriction of the [blank_start]permeation[blank_end] of [blank_start]macromolecules[blank_end] across [blank_start]the glomerular barrier[blank_end] on the basis of [blank_start]molecular[blank_end] size, charge, and physical [blank_start]configuration.[blank_end]
Responda
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permeation
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permeability
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macromolecules
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micromolecules
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the glomerular barrier
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bowmans space
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molecular
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atomic
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configuration.
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conglobulation.
Questão 7
Questão
Podocytes = [blank_start]specialized[blank_end], highly [blank_start]differentiated[blank_end] cells which line the [blank_start]outside[blank_end] of glomerular [blank_start]capillaries[blank_end] and thus face the [blank_start]Bowman's space[blank_end] and the primary [blank_start]urine[blank_end]
Responda
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specialized
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common
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differentiated
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similar
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outside
-
inside
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capillaries
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vessels
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Bowman's space
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glomerulus
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urine
-
urea
Questão 8
Questão
Podocytes have a ____ cell body
Responda
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large
-
small
-
average sized
Questão 9
Questão
The diaphragm in the podocyte covers the...
Responda
-
filtration slit
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fenestration
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foot process
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whole cell body
Questão 10
Questão
What type of collagen composes the backbone of the fibrous network in the glomerular basement membrane?
Responda
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type 1 collagen
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type 2 collagen
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type 3 collagen
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type 4 collagen
Questão 11
Questão
What is the normal urine flow rate in adult humans?
Responda
-
1 - 2 ml/min
-
100-125ml/min
-
540-900 ml/min
-
900-1500ml/min
Questão 12
Questão
What is the normal renal blood flow rate in adult humans?
Responda
-
900-1500 ml/min
-
4500 - 6000 ml/min
-
540-900 ml/min
-
1-2 ml/min
Questão 13
Questão
What is the normal renal plasma flow rate in adult humans?
Responda
-
540-900 ml/min
-
4500-6000 ml/min
-
900 - 1500 ml/min
-
1-2ml/min
Questão 14
Questão
what does the filtration fraction generally measure?
Responda
-
20-25%
-
40-45%
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50-60%
-
80-85%
Questão 15
Questão
Roughly how much primary urine is produced per day?
Responda
-
140L
-
200L
-
140ml
-
500L
-
10L
Questão 16
Questão
Roughly how much filtered fluid is reabsorbed?
Responda
-
99%
-
1%
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20%
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50%
-
75%
Questão 17
Questão
Drag and drop the right answer. all answers match up with a space, there are none spare.
For the 0 options, the 00 is in the % column and the normal 0 is in the urine column)
Responda
-
17
-
0.63
-
0.5
-
12.9
-
125
-
33
-
1.4
-
0.128
-
0.06
-
0.0048
-
0.134
-
0
-
18
-
1.8
-
0.72
-
9.5
-
0.96
-
1
-
00
-
55
-
130
Questão 18
Responda
-
Proximal convoluted tubule
-
glomerulus
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Glomerular capsule
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efferent arteriole
-
blood flow
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afferent arteriole
-
glomerular filtrate
-
fenestrae
-
podocyte
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capillary endothelium
Questão 19
Questão
Glomerular capillaries are __________
Responda
-
fenestrated
-
continuous
Questão 20
Questão
Endothelial cells _______ determine the permselectivity of the glomerular barrier.
Responda
-
do
-
do not
Questão 21
Questão
The endothelial cell coat has _________
Responda
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charge-selective properties
-
no charge-selective properties.
-
size selective properties
-
molecular weight selective properties
Questão 22
Questão
___________ density of fenestrae facilitates ___________ permeability
Responda
-
high, high
-
low, low
-
high, low
-
low, high
Questão 23
Questão
Which of these are important components that contribute to the selective properties of the glomerular basement membrane barrier?
Responda
-
ptoteoglycans such as agrin
-
ptoteoglycans such as perlecan
-
glycoproteins
Questão 24
Questão
Where is the endothelial cell surface layer?
Responda
-
on the luminal side of the blood vessels
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on the fenestrated side of the blood vessels
-
on the outside of the blood vessels
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within the glomerulus
Questão 25
Questão
What are the 2 components of the endothelial cell surface layer?
Responda
-
the glycocalyx
-
the endothelial cell coat
-
the endometrial cell jacket
-
the caloglycax
-
the glucose layer
Questão 26
Questão
Thye glycocalyx is the...
Responda
-
plasma-membrane-bound part of the layer
-
the more loosely associated part of the layer
Questão 27
Questão
Thye endothelial cell coat is the...
Responda
-
more loosely associated part of the layer
-
plasma-membrane-bound part of the layer
Questão 28
Questão
*** The endothelial cell surface layer is composed of....
Responda
-
negatively charged glycoproteins
-
glycosaminoglycans
-
membrane associated and secreted proteoglycans
Questão 29
Questão
drag and drop the substances along the graph in relation to where there relative permeability lies
Responda
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H2O
-
NaCl
-
Glucose
-
Inulin
-
Myoglobin
-
Hemoglobin
-
Albumin
Questão 30
Questão
Filtration of solutes that are not reabsorbed serves as an ineffective mechanism for their excretion
Responda
- True
- False
Questão 31
Questão
Which of these about polo trees are true?
Responda
-
Have long extending cytoplasmic foot processes
-
Foot processes are separated by a filtration slit
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The filtration slit is 25-60nm wide
-
The filtration slit is covered by a diaphragm
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One of the proteins that make up the diaphragm is nephrin
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Nephrin is very safe
Questão 32
Questão
When mutated, nephrin...
Responda
-
Causes massive leakage of protein
-
Causes severe consequences for patients with congenital nephrotic syndrome.
-
Causes the diaphragm in the kidney to close
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Causes excess water to be absorbed
-
Causes alcoholism
Questão 33
Questão
The basement membrane allows free passage of neutral molecules up to...
Responda
-
6Kd MW (18A radius)
-
16Kd MW (8A radius)
-
12Kd MW (24A radius)
-
2A MW (7Kd radius)
Questão 34
Questão
Negatively charged pores restrict passage of .... molecules
Responda
-
Large
-
Small
-
Medium
-
Long
-
Short
Questão 35
Questão
In disease states, protein Irial may be due to loss of negatively charge selectivity or to increasing numbers of large size pores
Responda
- True
- False
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