Quiz
MD11 Routes of delivery
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Perguntas do quiz (15)
1Choose the incorrect statement about the eosophagus
- AIs pH 6 - 7
- BSwallows via peristalsis
- CEpithelia is protective and secretes mucous
- DCan be affected by dysphagia, perforation
2The ileum is the main site for drug absorption.
- AVerdadeiro
- BFalso
3Which of these is not a main function of the stomach?
- AControl of food delivery
- BStorage of food
- CBeginning digestion
- DAbsorption
4pH changes along the GIT.
Fasted state average pH in the stomach = [blank_start]1.3[blank_end], duodenum = [blank_start]6.5[blank_end], jejunum = [blank_start]6.6[blank_end], ileum = [blank_start]7.4[blank_end].
Fed state average pH in the stomach = [blank_start]4.9[blank_end], duodenum = [blank_start]5.4[blank_end], jejunum = [blank_start]5.2-6[blank_end], ileum = [blank_start]7.5[blank_end].- A1.3
- B6.5
- C6.6
- D7.4
- E4.9
- F5.4
- G5.2-6
- H7.5
5Which of these is not a cell that has secretions directly affecting small intestine pH?
- AParietal cells
- BBrunner's glands
- CIntestinal goblet cells
6Gastric emptying is important in determining/controlling the [blank_start]onset of drug action[blank_end] because it controls how [blank_start]quickly[blank_end] a drug gets to the main site of absorption([blank_start]intestine[blank_end]). It also controls the time a drug spends in a [blank_start]low pH environment[blank_end] which has implications for stability.
- Aonset of drug action
- Bquickly
- Cintestine
- Dlow pH environment
7In general, a fasted state promotes shorter gastric residence time.
- AVerdadeiro
- BFalso
8The fasted pattern of motility in the stomach is also known as the [blank_start]migrating myoelectric complex[blank_end], MMC. The fasted stomach is [blank_start]less discriminatory[blank_end] for dosage forms. It has a roughly [blank_start]2h[blank_end] cycle.
- Amigrating myoelectric complex
- Bless discriminatory
- C2h
- D4h
9Because of the [blank_start]sieving[blank_end] effect in the stomach, during the [blank_start]fed[blank_end] state larger particles are retained [blank_start]longer[blank_end] due to [blank_start]retropulsion[blank_end] whereas small particles in [blank_start]trubulent fluids[blank_end] are emptied more [blank_start]rapidly[blank_end].
- Asieving
- Bfed
- Cfasted
- Dlonger
- Eturbulent fluids
- Frapidly
- Gretropulsion
10Lymphatics in the small intestine are important for absorption of fats, protein drugs and [blank_start]lipid soluble[blank_end] drugs — they transport proteins [blank_start]intact[blank_end] across the GIT. There are lymphatic capillaries and [blank_start]lymphoid tissue[blank_end], such as the fat deposits on the [blank_start]ileum[blank_end] known as Peyer's patches. They contain [blank_start]M cells[blank_end] and are important for the [blank_start]immune[blank_end] system.
- Alipid soluble
- Bintact
- Clymphoid tissue
- Dileum
- EM cells
- Fimmune
11Choose the incorrect statement about small intestine transit:
- ATakes 2 - 4 hours
- BHas relatively constant rate
- CThere is no difference between fed or fasted state
- DLiquids are transported slightly fasted than solids
12The colon's main function is reabsorption of [blank_start]water and ions[blank_end]. It does not have [blank_start]villi[blank_end], but it does have [blank_start]microvilli[blank_end], and has a pH of [blank_start]7 - 8[blank_end]. Transit rate here is [blank_start]long and variable[blank_end]. It contains [blank_start]fermentive[blank_end] bacteria.
- Awater and ions
- Bvilli
- Cmicrovilli
- D7 - 8
- E6 - 7
- Flong and variable
- Glong and constant
- Hfermentive
13When looking at rectal delivery we must consider:
- [blank_start]Stool[blank_end] is stored there
- pH is [blank_start]~7.5[blank_end]
- Epithelia is [blank_start]thin[blank_end]
- No [blank_start]villi[blank_end]
- [blank_start]Goblet[blank_end] cells
- Little [blank_start]water[blank_end]
- Absorption is via [blank_start]passive diffusion[blank_end]- AStool
- B~7.5
- C~ 5.5
- Dthin
- Ethick
- Fvilli
- GGoblet
- Hwater
- Ipassive diffusion
14Rectal administration methods include suppositories and micoenemas. Suppositories are solids that [blank_start]melt[blank_end] upon application and contain a drug in a vehicle which is either a [blank_start]fatty base or water soluble base[blank_end].
Micoenemas are [blank_start]expensive[blank_end] liquid or gas enemas which are often [blank_start]difficult[blank_end] to administrate.- Amelt
- Bfatty base or water soluble base
- Cexpensive
- Ddifficult
15Vaginal delivery can be [blank_start]topical/local[blank_end] or systemic, which avoids first pass metabolism. Systemic works as the environment is highly [blank_start]vascular[blank_end]. Can be for [blank_start]fertility[blank_end] treatment or [blank_start]hormone[blank_end] replacement.
Vaginal dosage forms can be creams or ointments, [blank_start]pessaries[blank_end](like suppositories), or [blank_start]rings[blank_end].- Atopical/local
- Bvascular
- Cfertility
- Dhormone
- Epessaries
- Frings
Informações
- Descrição
- PHCY211 (Medicines) Quiz sobre MD11 Routes of delivery, criado por Mer Scott em 15-05-2018.
- Autor
- Mer Scott
- Idioma
- English
- Visualizações
- 10
- Etiquetas
- Avaliação
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