20408532
Descrição
Quiz por Med Student , atualizado more than 1 year ago
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Criado por Med Student
mais de 4 anos atrás
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Questão 1
Questão
Placebo is
Responda
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allergic drug reaction
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drug form, without active substance
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method for treatment of acute pain
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drug tolerance
Questão 2
Questão
Tobacco smoking
Responda
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increases drugs metabolism
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decreases drug metabolism
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decreases plasma concentrations of methylxanthines
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doesn’ t change drugs metabolism
Questão 3
Questão
Nocebo effect is
Responda
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Allergic drug reaction
-
Analgesic method
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Adverse drug reaction, caused by placebo
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CNS depression
Questão 4
Questão
When patient and doctor are aware of the contents of the formulation, the trial is defined as
Responda
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open trial
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blind trial
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placebo trial
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double-blind trial
Questão 5
Questão
Surrogates in rational pharmacotherapy are
Responda
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clinical- laboratory indexes
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instrumental investigations - ECG; EMG; MRT etc
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disease improvement
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decreased mortality rate
Questão 6
Questão
Pharmacodynamic changes in elderly are
Responda
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increased sensitivity to drugs suppressing central nervous system
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decreased sensitivity to drugs suppressing central nervous system
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paradoxal reactions are observed
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adverse drug reactions are more frequent
Questão 7
Questão
Steady-state plasma concentration is
Responda
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blood concentration of the drug 2 hours after administration
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blood concentration of the drug after repeated administration when there is a balance between absorption and excretion
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blood concentration of the drug after it has been ceased
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blood concentration of the drug during its absorption
Questão 8
Questão
Drugs half-life is an index for
Responda
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the route of administration of the drug
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the duration of the drug effect when there is a relationship between it and plasma concentrations
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time to reach steady-state plasma concentration after repeated administration
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determination of dose interval
Questão 9
Questão
Drugs contraindicated in the first half of pregnancy are
Responda
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Erythromycin
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Sex steroids
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Penicillins
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Oral anticoagulants
Questão 10
Questão
For pharmacokinetics in elderly is true
Responda
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decreased excretion
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decreased metabolism
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decreased volume of distribution
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increased volume of distribution
Questão 11
Questão
Reasons for inadequate pharmaceutical availability are
Responda
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chronic renal failure
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improper use of the drug formulation
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bad quality of the drug substance
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participating in treatment
Questão 12
Questão
Categories of ADRs are
Responda
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certain
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probable
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possible
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unlikely
Questão 13
Questão
Therapeutic drug monitoring is
Responda
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method for neuroleptanalgesy
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used when there is relationship between plasma concentrations and drug effect
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used for drugs with narrow therapeutic window
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used for drugs with long half- live
Questão 14
Questão
Irrational ready-made drug formulations contain
Responda
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drugs with different half-life
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drugs for ethiotropic and symptomatic treatment
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drugs with narrow therapeutic window
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drugs affecting different pathogenic mechanisms
Questão 15
Questão
First phase of clinical trial can be determinated as
Responda
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first application of a new substance to healthy volunteers
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first application of a new substance to patients
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efficacy and safety in a large number of patients
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post-marketing surveillance in thousands of patients
Questão 16
Questão
Binding of drugs with plasma proteins is important for
Responda
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half- life
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drugs interactions
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bioavailabillity
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the value of the pharmacological effect
Questão 17
Questão
Adverse drug reactions lead to
Responda
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increased pharmacological effect
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decreased risk of toxicity
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decreased efficacy of the treatment
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developement of unpredictable drug effects
Questão 18
Questão
Bad compliance of the patient may be due to
Responda
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dose regimen with many drugs with frequent administration
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a large number of drugs
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lack of information for the treatment
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the drug must be taken once daily
Questão 19
Questão
Fourth phase of clinical trial can be determinated as
Responda
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first application of a new substance to healthy volunteers
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first application of a new substance to patients
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efficacy and safety in a large number of patients
-
post-marketing surveillance in thousands of patients
Questão 20
Questão
Drugs clearance is
Responda
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Amount of drug, that reaches systemic circulation
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Blood plasma volume from which the drug is eliminated for defined period of time
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Steady- state plasma concentration
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Withdrawal syndrome
Questão 21
Questão
Monitoring of therapeutic plasma concentrations is necessary for
Responda
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theophyllin
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phenobarbital
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carbamazepin
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amoxicillin
Questão 22
Questão
Third phase of clinical trial can be determinated as
Responda
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first application of a new substance to healthy volunteers
-
first application of a new substance to patients
-
efficacy and safety in a large number of patients
-
post-marketing surveillance in thousands of patients
Questão 23
Questão
Clearance is an index for
Responda
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drugs excretion
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determination of mantaining dose of the drugs
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drugs absorbtion
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effects of the drugs on the heart
Questão 24
Questão
Pharmacogenetic differences lead to
Responda
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decreased effect
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increased effect
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development of adverse drug reactions
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avitaminosis
Questão 25
Questão
Drug surveillance is done by
Responda
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spontaneous reporting
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observation studies
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family doctors
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population statistics
Questão 26
Questão
Adverse drug reactions are the following types
Responda
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augmented
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bizarre
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chronic
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delayed
Questão 27
Questão
Mechanisms of drug interactions are
Responda
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unpredictable
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pharmacokinetic
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pharmacodynamic
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pharmaceutical
Questão 28
Questão
The quality of therapeutic decision (outcomes) can be measured by
Responda
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clinical outcomes
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costs — direct and indirect
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functional status pf patient
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overall patient satisfaction
Questão 29
Questão
Method of evaluation of cost/benefits ration are
Responda
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cost minimization analysis
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cost effectiveness analysis
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cost utility analysis
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cost consequence analysis
Questão 30
Questão
Drug metabolism involving some enzyme defects includes the following reactions
Responda
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acetylation
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oxidation
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hydrolysis
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red cells enzyme defects
Questão 31
Questão
The reasons for drug abuse are
Responda
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relief of anxiety, tension and depression
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entertainment, fun
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improvement of performance in competitive sports
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conformity with own social subgroup
Questão 32
Questão
How many types of dependence do you know?
Responda
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psychological
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physical (physiological)
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acute
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chronic
Questão 33
Questão
Which pharmacological drug groups cause drug dependence and tolerance?
Responda
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Opioid analgesics
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Antidepressants
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CNS stimulants
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Benzodiazepines
Questão 34
Questão
The neuropharmacological mechanisms of drug addiction are
Responda
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activation of endogenous opiate encephalin receptors
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activation of μ-opioid receptors in the brain
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activation of cannabinoid receptors (CB1) in the hypothalamus
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increase of glutamate release in the brain cortex
Questão 35
Questão
Benzodiazepine withdrawal syndrome is characterized by
Responda
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it develops after 6-weeks of treatment
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it develops after 2 weeks of treatment
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psychological symptoms — anxiety, agitation, insomnia, seizures
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physical symptoms — nausea, vomiting, muscle pain, ataxia
Questão 36
Questão
Opioid (heroin, morphine) withdrawal syndrome is characterized by
Responda
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begins 8 hours after last dose
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the peak is between 36-72 h
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first physical symptoms are lacrimation, rhinorrhea and sweating
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abdominal cramps, diarrhoea, bone and muscle pain, weakness and chills
Questão 37
Questão
Why is methadone used for treatment of opioid-dependence?
Responda
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it is taken orally
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it is applied intravenously
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has prolonged action
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has short-action
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