Cellular Adaptations & Necrosis

Descrição

Medicine Quiz sobre Cellular Adaptations & Necrosis, criado por Trey W em 18-07-2020.
Trey W
Quiz por Trey W, atualizado more than 1 year ago
Trey W
Criado por Trey W quase 4 anos atrás
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Resumo de Recurso

Questão 1

Questão
Which of the following is not a pattern of cell death in tissues?
Responda
  • fibrinoid necrosis
  • fat necrosis
  • coagulative necrosis
  • contracture necrosis

Questão 2

Questão
Compare acute cell injury with cellular adaptations.
Responda
  • Cellular adaptations develop over a brief period of time and are reversible
  • Acute cell injury can be manifested as reversible cell swelling
  • Acute cell injury can be manifested as irreversible necrosis

Questão 3

Questão
What is lipofuscin?
Responda
  • Blue-pigmented cytoplasmic inclusions in stressed cells
  • A lipid-containing residual body of autophagy
  • An irreversible "wear and tear" pigment
  • A product of cells undergoing decreased cell turnover

Questão 4

Questão
Metatstatic calcification is due to precipitation of calcium at sites of cell/tissue injury
Responda
  • True
  • False

Questão 5

Questão
Which of the following mechanisms explains the pathogenesis of alcohol-induced fatty liver?
Responda
  • Increased delivery of free fatty acids
  • Increased lipogenesis
  • Decreased apoprotein synthesis for triglyceride export
  • Increased utilization of triglycerides and oxidation of fatty acids

Questão 6

Questão
Metaplasia can be characterized by which of the following?
Responda
  • One adult cell type being replaced by another through chronic injury
  • Irreversible change in cells/tissue
  • Decreased risk of malignancy/neoplasia
  • Increase in cell number

Questão 7

Questão
Which is an example of physiologic apoptosis?
Responda
  • Formation of the esophageal lumen
  • Syndactyly
  • Muscular dystrophy
  • Chronic lymphocytic leukemia

Questão 8

Questão
Apoptosis can result from endogenous OR exogenous causes
Responda
  • True
  • False

Questão 9

Questão
In a Masson Trichrome stain
Responda
  • Nucleic acids stain dark blue
  • Connective tissue stains blue
  • Proteins stain light purple

Questão 10

Questão
Which of the following would you expect to see in necrosis?
Responda
  • A rounded up, fragmented cell morphology
  • Phagocytosis by neutrophils
  • Phagocytosis by macrophages and nonprofessional macrophages
  • Functionally intact cell membrane

Questão 11

Questão
You are examining the tissue of a patient who had a subarachnoid hemorrhage. When looking at the brain tissue microscopically, what would you expect to observe in the area of hemorrhage?
Responda
  • Pneumonoultramicroscopicsilicovolcanoconiosis
  • Hemosiderosis
  • Steatosis
  • Anthracosis

Questão 12

Questão
At what point in cell injury would you expect to observe hydropic change of the cell?
Responda
  • < 10 minutes
  • 10-15 minutes
  • 15-60 minutes
  • 4-8 hours

Questão 13

Questão
You know that irreversible cell injury is often characterized by nuclear changes. Which of the nuclear changes describes pyknosis?
Responda
  • Fragmentation of the nucleus into dense basophilic fragments ("nuclear debris")
  • Dissolution of nuclear fragments
  • Condensation of chromatin
  • Dilation of the endoplasmic reticulum

Questão 14

Questão
In coagulative necrosis, the shapes of cells and tissues change dramatically, but the nuclei/organelles are intact.
Responda
  • True
  • False

Questão 15

Questão
Where would you expect to see liquefactive necrosis most often?
Responda
  • Brain
  • Lungs
  • Abscesses
  • GI tract

Questão 16

Questão
Your patient's cells and tissues demonstrate obvious enzymatic necrosis. You immediately know the condition that (likely) caused this is:
Responda
  • COVID
  • Acute pancreatitis
  • Myocardial infarction
  • Hypercalcemia

Questão 17

Questão
What is the most common cause of caseous necrosis?
Responda
  • Dry gangrene
  • Wet gangrene
  • Mycobacteria tuberculosis
  • Eating too much cottage cheese

Questão 18

Questão
Fibrinoid necrosis is caused by injury to vessel walls that causes leakage of protein and fibrin from the circulation that becomes entrapped. Which vascular injury might cause this type of necrosis?
Responda
  • Immune-complex associated vasculitis
  • Accelerated HTN
  • HTN that has slowly developed over 20 years
  • Excessive scarring

Questão 19

Questão
What is a heterophagosome?
Responda
  • A secondary lysosome involved in digestion of a cell's own organelles
  • A primary lysosome fused with absorptive vesicles originating from the plasma membrane
  • A small vesicle budding from enzymes on the lateral side of the Golgi apparatus

Questão 20

Questão
In your elective oncology rotation, a patient presents with multiple calcified breast tumors. You know this to be a result of metastatic calcification.
Responda
  • True
  • False

Questão 21

Questão
Upon histological examination, tissue cells demonstrate what looks like "nuclear dust". This is characteristic of
Responda
  • karyorrhexis
  • karyolysis
  • karyogram
  • pyknosis

Questão 22

Questão
In response to [blank_start]cigarette smoke[blank_end], columnar epithelial cells of the bronchial epithelium undergo squamous [blank_start]metaplasia[blank_end]. Smoking-induced metaplasia may lead to bronchial squamous cell [blank_start]neoplasia[blank_end].
Responda
  • cigarette smoke
  • sitting for 12 hours/day
  • drinking too much water
  • pulmonary HTN
  • metaplasia
  • hyperplasia
  • neoplasia

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