27207050
Descrição
Quiz por Bryan Suringa, atualizado more than 1 year ago
|
Criado por Bryan Suringa
mais de 3 anos atrás
|
|
Questão 1
Questão
Which of the following is/are true regarding phase 1 drug metabolism?
Responda
-
Also known as conjugation reaction
-
Includes only oxidation
-
Generally tends to provide a functional group or “handle” to the molecule
-
NOTA
Questão 2
Questão
Which of the following is/are true regarding phase II drug metabolism?
Responda
-
Allows the attachment of small, polar and ionizable endogenous compounds
-
Allows the termination or attenuation of a biologic activity
-
serves to protect the body against chemically reactive compounds or metabolites
-
NOTA
Questão 3
Questão
Which of the following undergo an oxidative reaction?
Responda
-
Olefins
-
alcohols, aldehydes
-
aromatic moieties
-
nitro and azo compounds
Questão 4
Questão
Which of the following is/are examples of drugs that are extensively metabolized by the first pass effect?
Responda
-
Lidocaine
-
Nitroglycerin
-
Morphine
-
meperidine
Questão 5
Questão
Glucuronidation is the most common conjugative pathway in drug metabolism. Which of the following is/are responsible for this?
Responda
-
readily available supply of D-glucuronic acid
-
numerous functional groups that can combine enzymatically with glucuronic acid
-
utilization of D-glucuronic acid to conjugate steroids, heparin, chondroitin, catecholamines and thyroxine
-
AOTA
Questão 6
Questão
Which of the following is/are factors affecting drug metabolism?
Responda
-
Age
-
economic status
-
species and strain
-
gender
Questão 7
Questão
Which of the following is/are true regarding methylation?
Responda
-
generally leads to polar or water-soluble metabolites
-
important in the biosynthesis of many endogenous compounds like epinephrine and melatonin
-
constitutes only a minor pathway for conjugating drugs or xenobiotics
-
NOTA
Questão 8
Questão
Which of the following is/are considered slow acetylators?
Responda
-
eskimos
-
egyptians
-
filipinos
-
jews
Questão 9
Questão
Which of the following may induce metabolism of other drugs?
Responda
-
phenytoin
-
cimetidine
-
meprobamate
-
rifampicin
Questão 10
Questão
The term that denotes the selective metabolism of two or more similar functional groups or two or more similar atoms that are positioned in different regions of a molecule.
Responda
-
stereoisomerism
-
regioselectivity
-
selective toxicity
-
substrate stereoselectivity
Questão 11
Questão
The process involved in the biotransformation of amitriptyline to nortriptyline.
Responda
-
N-demethylation
-
Aromatic hydroxylation
-
Epoxidation
-
Ester hydrolysis
Questão 12
Questão
The biotransformation of chloral hydrate via aldehyde reduction forms?
Responda
-
desipramine
-
mesoridazine
-
trichloroethanol
-
sulindac
Questão 13
Questão
What process is involved in the biotransformation of prednisone to prednisolone?
Responda
-
ketone reduction
-
O-demethylation
-
sulfoxide reduction
-
Aromatic hydroxylation
Questão 14
Questão
What process is involved in the biotransformation of phenylbutazone to oxybutazone?
Responda
-
aromatic hydroxylation
-
ketone reduction
-
N-acetylation
-
S-oxidation
Questão 15
Questão
Which of the following is/are metabolites?
Responda
-
6-mercaptopurine
-
phenylbutazone
-
prednisolone
-
acetaminophen
Questão 16
Questão
Which of the following is/are parent drug/s?
Responda
-
digitoxin
-
hydrocortisone
-
primidone
-
propranolol
Questão 17
Questão
The property of chemicals to destroy one form of life without harming another.
Responda
-
stereoisomerism
-
regioselectivity
-
selective toxicity
-
substrate stereoselectivity
Questão 18
Questão
Which of the following may be used to classify chemotherapeutic agents?
Responda
-
chemical type
-
biologic properties
-
therapeutic indications
-
NOTA
Questão 19
Questão
Which of the following is/are characteristics of an ideal antiseptic?
Responda
-
rapid and sustained lethal action against microorganisms
-
retain activity in the presence of body fluids
-
high surface tension
-
NOTA
Questão 20
Questão
An agent that prevents infection by the destruction of pathogenic microorganisms when applied to inanimate objects.
Responda
-
Antiseptic
-
disinfectant
-
antibiotic
-
sanitizer
Questão 21
Questão
Generally accepted other names of alcohol USP
Responda
-
Ethanol
-
wood alcohol
-
spiritus vini rectificatus
-
wine spirit
Questão 22
Questão
Ethanol that has been rendered unfit for use in intoxicating beverages by the addition of other substances.
Responda
-
Denatured alcohol
-
wood alcohol
-
isopropyl alcohol
-
formaldehyde
Questão 23
Questão
Phenol coefficient is defined as the ratio of a disinfectant to the dilution of phenol required to kill a given strain of a bacterium. What microorganism is used in determining the phenol coefficient?
Responda
-
Bacillus subtilis
-
Enterobacter aerogenes
-
Pseudomonas aeruginosa
-
Salmonella typhi
Questão 24
Questão
A 2% solution of iodine in 50% alcohol with sodium iodide.
Responda
-
Iodine solution
-
iodine tincture
-
lugol’s solution
-
mayer’s reagent
Questão 25
Questão
A preparation of 5% Iodine in water with potassium iodide?
Responda
-
Iodine solution
-
iodine tincture
-
lugol’s solution
-
mayer’s reagent
Questão 26
Questão
A preparation of 2% iodine in water with sodium iodide?
Responda
-
Iodine solution
-
iodine tincture
-
lugol’s solution
-
mayer’s reagent
Questão 27
Questão
Povidone-Iodine
Responda
-
Water-soluble complex that releases iodine slowly
-
provides a non-toxic, non-irritating,non-volatile and non-staining form of iodine
-
used as an antiseptic for skin application before surgery and injection
-
NOTA
Questão 28
Questão
A dye available as vaginal suppositories for the treatment of yeast infections.
Responda
-
Malachite green
-
methylene blue
-
phenolphthalein
-
gentian violet
Questão 29
Questão
Dye used as an antidote for cyanide poisoning?
Responda
-
Malachite green
-
methylene blue
-
phenolphthalein
-
gentian violet
Questão 30
Questão
A potent antifungal substance with a polyene structure from Streptomyces nodosus
Responda
-
Nystatin
-
griseofulvin
-
natamycin
-
amphotericin B
Questão 31
Questão
The aglycone portion of nystatin consisting of a 38-membered ketone ring with a single tetracene and diene chromophores isolated from each other by a methylene group, one carboxyl, one keto, and eight hydroxyl groups.
Responda
-
Mykinac
-
mycostatin
-
nystatinolide
-
candeptin
Questão 32
Questão
Polyene antibiotic first isolated in 1951 from a strain of Streptomyces noursei by hanzen and brown.
Responda
-
Nystatin
-
amphotericin b
-
natamycin
-
griseofulvin
Questão 33
Questão
Griseofulvin
Responda
-
Recommended for the systemic treatment of refractory ringworm infections
-
its bioavailability is notoriously poor
-
it is supplied in “microsize” and “ultramicrosize” forms
-
NOTA
Questão 34
Questão
A series of synthetic antibacterial agents patterned after nalidixic acid, with an effective antibacterial spectrum largely confined to gram-negative bacteria.
Responda
-
quinolones
-
dihydrotriazines
-
biguanides
-
polyenes
Questão 35
Questão
The structure found among the quinolones which is essential for their antibacterial activity is 1,4-dihydro-4-oxo-3-pyridine carboylic acid.
Responda
-
True
-
False
Questão 36
Questão
Its congeners represent important alternatives for the treatment of urinary tract infections caused by strains of Proteus resistant to other agents.
Responda
-
Norfloxacin
-
cinoxacin
-
nitrofurantoin
-
nalidixic acid
Questão 37
Questão
Antibiotic
Responda
-
A synthetic product produced as a structural analogue of a naturally occurring antibiotic
-
it antagonizes the growth or the survival of one or more species of microorganisms
-
it is effective in low concentration
-
NOTA
Questão 38
Questão
One who led the isolation of streptomycin from Streptomyces griseus:
Responda
-
Pasteur & Joubert
-
waksman
-
Vuillemin
-
Florey and Chain
Questão 39
Questão
Antibiotic that binds with ribosome 30s subunit
Responda
-
Chloramphenicol
-
tetracycline
-
erythromycin
-
lincomycins
Questão 40
Questão
Benzylpenicillin binds preferentially to:
Responda
-
PBP 1a & 1b
-
PBP 2
-
PBP 3
-
PBP 6
Questão 41
Questão
Methicillin is chemically called as:
Responda
-
2-ethoxy-1-napthylpenicillin
-
5-methyl-3-phenyl-4-isoxazolyl penicillin
-
5-methyl-3-(2,6-dichlorophenyl)-4-isoxazolyl-penicillin
-
2,6-dimethoxyphenyl penicillin
Questão 42
Questão
Amoxicillin
Responda
-
D-?-Amino-p-hydroxybenzyl-penicillin
-
?-Carboxy-3-thienyl penicillin
-
?-(1-methanesulfonyl-amino) benzylpenicillin
-
D-?-aminobenzyl penicillin
Questão 43
Questão
Structure of the penicillin molecule shows it to contain a fused ring system which is the:
Responda
-
?-lactam thiazolidine
-
?-lactam penam
-
6-aminopenicillanic acid
-
?-lactam phenyl penicillin ring
Questão 44
Questão
Members of the 4-isoxazolyl penicillin family require these substituents for effectiveness against ?-lactamase producing Staphylococcus aureus.
Responda
-
3-aryl & 5-methyl group
-
3-acyl & 6-methyl group
-
3-phenyl & 2-methoxy group
-
3-phenyl & 2-methyl group
Questão 45
Questão
These are major antigenic determinants that are formed when penicillins or its rearrangement products in vivo react with lysine-e-amino groups of proteins resulting to allergic reactions.
Responda
-
Penicillenic acids
-
penicilloyl proteins
-
penicillanic proteins
-
penicillanic acids
Questão 46
Questão
This is prepared by the reaction of ampicillin with acetone
Responda
-
Unipen
-
hetacillin
-
unasyn
-
methicillin
Questão 47
Questão
Class 1 ?-lactamase inhibitors have hetero atom leaving at position 1. Which of these is/are Class II inhibitors:
I. Carbapenems
II. Sulbactam
III. Clavulanic Acid
Responda
-
I only
-
I, II
-
II, III
-
III only
Questão 48
Questão
Augmentin is a combination of:
Responda
-
K salt of Clavulanic Acid
-
amoxicillin
-
ampicillin
-
sulbactam
Questão 49
Questão
Unasyn is a fixed-dose combination of:
Responda
-
Amoxicillin
-
sulbactam
-
ampicillin
-
clavulanic
Questão 50
Questão
Primaxin is a combination of:
Responda
-
Tazocillin
-
imipenem
-
piperacillin
-
cilastatin
Questão 51
Questão
Imipenem is the most successful of a series of chemically stable derivatives of thienamycin in which the primary amino group is converted to a non-nucleophilic basic function. Imipenem is also:
Responda
-
5-acetamido thienamycin
-
5-methyl-3-phenyl-4-isoxazolyl penicillin
-
n-formimidoyl thienamycin
-
?-imidazolyl ethylamine
Questão 52
Questão
D-(4-amino-4-carboxybutyl) is:
Responda
-
Penicillin N
-
synnematin B
-
cephalosporin N
-
chloramphenicol B
Questão 53
Questão
Cephalosporin C contains:
Responda
-
Penicillanic acid
-
thiazolidine ring
-
lactone ring
-
dihydrothiazine ring
Questão 54
Questão
A parenteral cephamycin
Responda
-
Cefoxitin
-
ceftazidime
-
cephalexin
-
cefadroxil
Questão 55
Questão
Zinacef is the first of a series of a-methoxyimino-acyl-substituted cephalosporins that constitute most of the third generation agents. Zinacef is:
Responda
-
Sterile cefotaxime Sodium, USP
-
Cefuroxime Sodium, USP
-
Moxalactam Disodium, USP
-
Cefepime, USP
Questão 56
Questão
The factors that contribute to an extremely long serum half-life of sterile ceftriaxone disodium, USP
Responda
-
High fraction of protein binding in the plasma
-
slow urinary excretion
-
it is not metabolized in vivo
-
NOTA
Questão 57
Questão
This increases stability to ?-lactamases while increasing activity against G(-) bacteria at the same time in monobactams:
Responda
-
4-methyl group
-
3-methoxy group
-
oximinoacyl group
-
2-aryl group
Questão 58
Questão
The 1st aminoglycoside antibiotic to be used in chemotherapy:
Responda
-
Amikacin
-
gentamicin
-
streptomycin
-
kanamycin
Questão 59
Questão
MOA of Aminoglycosides:
Responda
-
Interferes with cell wall synthesis
-
act directly on the bacterial ribosome to inhibit the initiation of protein synthesis
-
interferes with the fidelity of translation of the genetic message
-
NOTA
Questão 60
Questão
Extrachromosomals which are self-replicative and transferable by conjugation that is responsible for the transfer of resistance from one bacterium to another.
Responda
-
R-factor
-
F-factor
-
S-factor
-
X-factor
Questão 61
Questão
SAR of Aminoglycosides: important for characteristic broad-spectrum antibacterial activity & is the primary target for bacterial inactivating enzymes.
Responda
-
Ring I
-
Ring II
-
Ring III
-
Ring IV
Questão 62
Questão
Known as Streptomycin B
Responda
-
Streptomycin
-
Mannisidostreptomycin
-
Hydroxystreptomycin
-
Paromomycin Sulfate, USP
Questão 63
Questão
Acid hydrolysis of Streptomycin yields:
Responda
-
Streptidine
-
Streptobiosamine
-
Deoxystreptamine
-
NOTA
Questão 64
Questão
Neomycin is obtained from:
Responda
-
S. fradiae
-
S. rimosus
-
S. kanamyceticus
-
Micromonospora purpurea
Questão 65
Questão
The synthesis of this semisynthetic aminoglycoside involves simple acylation of the 1-amino group of the deoxystreptamine ring of Kanamycin A with L-amino-a-hydroxybutyric acid (L-AHBA)
Responda
-
Tobramycin
-
Netilmicin
-
Amikacin
-
Gentamicin
Questão 66
Questão
A group of antibiotics that are derivatives of an octahydronaphthalene, a hydrocarbon system that comprises four annelated six-membered rings.
Responda
-
Macrolides
-
tetracycline
-
lincomycins
-
sulfonamides
Questão 67
Questão
7-Chloro-6-demethyl tetracycline is:
Responda
-
demeclocycline
-
Oxytetracycline
-
minocycline
-
Doxycycline
Questão 68
Questão
Macrolide antibiotics have these common characteristics:
Responda
-
Large lactone ring
-
ketone group
-
a glycosidically linked amino sugar
-
an asymmetric carbon atoms in the acylamidopropanediol chain
Questão 69
Questão
Bacillus subtilis strain that was isolated from debrided tissue of a compound fracture in 7-year old Margaret Tracy produced this antibiotic.
Responda
-
Gramicidin
-
Bacitracin
-
Colistin
-
Polymyxin
Questão 70
Questão
The first of the widely used broad-spectrum antibiotic that was isolated by Ehrlich in 1947 from S. venezuelae
Responda
-
Clindamycin
-
Chloramphenicol
-
Vancomycin
-
Novobiocin
Questão 71
Questão
Erythromycin B differs from Erythromycin A only at carbon 12, at which hydroxyl group is replaced by ______, which renders it more acid stable.
Responda
-
Bromine
-
Chlorine
-
Hydrogen
-
Oxygen
Questão 72
Questão
These are sulfur-containing antibiotics isolated from S. lincolnensis
Responda
-
Bacitracin
-
novobiocin
-
lincomycins
-
vancomycins
Questão 73
Questão
7-Chloro-7-deoxy lincomycin
Responda
-
Cleocin
-
Unasyn
-
Unipen
-
Lincocin
Questão 74
Questão
Bacitracin’s bactericidal effect through an inhibition of mucopeptide cell wall synthesis is enhanced by:
Responda
-
P
-
Zn
-
Cl
-
S
Questão 75
Questão
Analogue of podophyllotoxin that is an inhibitor of Topoisomerase II which contains methyl as its R group:
Responda
-
Vindoline
-
Etoposide
-
Vincristine
-
Epipodophyllotoxin
Questão 76
Questão
The complex structures in vinca alkaloid composed of indole-containing moiety and an indoline-containing moiety:
Responda
-
Indoline
-
Vindoline
-
Vindesine
-
Catharanthine
Questão 77
Questão
Is an antineoplastic agent preparation from E. coli containing the enzyme L-asparagine amidohydrolase
Responda
-
Asparaginase
-
Elspar
-
Pipobroman
-
Platinol
Questão 78
Questão
An antineoplastic drug active against rapidly proliferating cells in the synthesis phase during which it prevents the formation of deoxyribonucleotides by inhibition of ribonucleotide diphosphate reductase.
Responda
-
Carboplatin
-
hydroxyurea
-
mitoguazone
-
hycanthone
Questão 79
Questão
Used primarily for polycythemia vera:
Responda
-
Hexamethylamine
-
asparaginase
-
tamoxifen
-
pipobroman
Questão 80
Questão
D-Homo-17a-oxa androsta-1,4-dione prepared by microbial transformation of progesterone
Responda
-
Tamoxifen
-
testolactone
-
megestrol
-
ethinyl estradiol
Questão 81
Questão
Interferons are secreted by cells in response to viral infections or other chemical or biologic inducers. The major classes of interferons are:
Responda
-
alpha
-
Beta
-
Lambda
-
Gamma
Questão 82
Questão
It is a highly purified protein containing 165 amino acids manufactured from a strain of E.coli bearing a genetically engineered plasmid containing an interferon alfa-2a gene from human leukocytes.
Responda
-
RIFN
-
IFLrA
-
Roferon-A
-
Interon
Questão 83
Questão
This is absolutely essential for the in-vitro carbonic anhydrase inhibitory activity and for the production of a diuresis in vivo.
Responda
-
Sulfamoyl group
-
neptazane
-
amino group
-
Imino group
Questão 84
Questão
Diamox
Responda
-
Acetazolamide
-
Hydrochlorothiazide
-
Amoxicillin
-
Dichlorphenamide
Questão 85
Questão
Benzothiazine-1,1-dioxide nucleus is contained in:
Responda
-
Carbonic anhydrase inhibitors
-
thiazide diuretics
-
loop diuretics
-
phenoxyacetic acids
Questão 86
Questão
4-Chloro-N-furfuryl-5-sulfamoyl anthranilic acid is:
Responda
-
Bumetanide
-
furosemide
-
ethacrynic acid
-
chlorothiazide
Questão 87
Questão
Primary compound selected from a host of pteridine analogues and resembles the structure of folic acid and certain dihydrofolate reductase inhibitors.
Responda
-
Spironolactone
-
amiloride
-
theophylline
-
triamterene
Questão 88
Questão
A pyrazinoyl guanidine diuretic that inhibits the electrogenic entry of 2% to 3% of the filtered load of Na into the tubule cells.
Responda
-
Triamterene
-
spironolactone
-
amiloride
-
aldosterone
Questão 89
Questão
The major adverse effect of midamor:
Responda
-
hypomagnesemia
-
hyponatremia
-
hypocalcemia
-
hyperkalemia
Questão 90
Questão
?-imidazolylethylamine, an autacoid, is widespread in nature being found in ergot and other plants and in all organs and tissues of the human body. It’s also known as:
Responda
-
1H-imidazole-4-ethenamine
-
histamine
-
serotonin
-
NOTA
Questão 91
Questão
The major source of histamine in the body results from the decarboxylation of this amino acid:
Responda
-
Tryptophan
-
Histidine
-
Tyrosine
-
Phenylalanine
Questão 92
Questão
Drowsiness is a side effect of antihistamines that is most common to the:
Responda
-
Ethylenediamines
-
tertiary aminoalkyl ethers
-
phenothiazines
-
cimetidine
Questão 93
Questão
A propylamine derivative:
Responda
-
Diphenhydramine
-
Clemastine
-
Carbinoxamine
-
Brompheniramine
Questão 94
Questão
Dramamine
Responda
-
Doxylamine
-
Dimenhydrinate
-
Diphenhydramine
-
Cyclizine
Questão 95
Questão
The piperazine, imidazoline and phenothiazine type antihistamines contain the following moiety:
Responda
-
Aminoalkyl ethers
-
ethylene diamine
-
propylamine
-
butyrophenone
Questão 96
Questão
Antihistamine resulting from the chlorination of pheniramine in the para position of the phenyl ring that gives a tenfold increase in potency with no appreciable changes in toxicity.
Responda
-
Brompheniramine
-
chlorpheniramine
-
pyrrobutamine
-
promethazine
Questão 97
Questão
A sulfone derivative investigated initially to be the most effective drug for the treatment of leprosy and has useful antimalarial property but was too toxic.
Responda
-
4,4’-diamidodiphenylsulfide
-
4,4’-diaminodiphenylsulfone
-
3,4’-diaminediphenylsulfide
-
3,4’-diamidodiphenylsulfone
Questão 98
Questão
What antibiotic caused a major advance in the treatment of tuberculosis?
Responda
-
Isoniazid
-
ethionamide
-
rifampin
-
cycloserine
Questão 99
Questão
Ethambutol is remarkably stereospecific. Toxicities of its isomers are about equal but their activity varies considerably. Factors that have pronounced effect on the activity are:
Responda
-
Length of the alkylene chain
-
nature of the branching with the alkyl substituents in the nitrogens
-
extent of N-alkylation
-
pyranolone ring at the C4 of the compound
Questão 100
Questão
Ethionamide is a second-line treatment drug for tuberculosis and used in the treatment of INH-resistant tuberculosis or when the patient is intolerant to INH and other drugs. What is its structural difference with the INH series?
Responda
-
5 - substitution
-
2 - substitution
-
addition of a thiazolidine ring
-
addition of a pyranolone ring
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