Drug molecules - properties and actions & functional groups

Descrição

Masters Degree Pharmacy (Case 1 - Introduction) Quiz sobre Drug molecules - properties and actions & functional groups, criado por Alyssa B em 02-01-2016.
Alyssa B
Quiz por Alyssa B, atualizado more than 1 year ago
Alyssa B
Criado por Alyssa B mais de 8 anos atrás
84
2

Resumo de Recurso

Questão 1

Questão
What shape is a sp3 hybridised C?
Responda
  • Tetrahedral
  • Trigonal planar
  • Linear

Questão 2

Questão
What shape is a sp2 hybridised C
Responda
  • Tetrahedral
  • Trigonal planar
  • Linear

Questão 3

Questão
What shape is a sp hybridised C
Responda
  • Tetrahedral
  • Trigonal planar
  • Linear

Questão 4

Questão
Alkanes are unsaturated hydrocarbons. True or false?
Responda
  • True
  • False

Questão 5

Questão
Alkenes are [blank_start]more[blank_end] reactive than alkanes because the delocalised electrons make them susceptible to attack by electrophiles.
Responda
  • more

Questão 6

Questão
Alkenes undergo [blank_start]electrophilic addition reactions[blank_end]
Responda
  • electrophilic addition reactions

Questão 7

Questão
Alkynes are [blank_start]less[blank_end] reactive than alkenes.
Responda
  • less

Questão 8

Questão
Alkynes undergo
Responda
  • Substitution reactions
  • Electrophilic addition reactions but at a quicker rate than alkenes
  • Nucleophilic substitution reactions
  • Electrophilic addition reactions but at a slower rate than alkenes

Questão 9

Questão
Arenes are [blank_start]highly unsaturated[blank_end] and [blank_start]cyclic.[blank_end]
Responda
  • highly unsaturated
  • cyclic.

Questão 10

Questão
Arenas do not behave like alkenes and alkynes because they [blank_start]do not decolourise bromine water.[blank_end]
Responda
  • do not decolourise bromine water.

Questão 11

Questão
What type of molecule is benzene?
Responda
  • Trigonal planar
  • Planar
  • Linear
  • Tetrahedral

Questão 12

Questão
Benzene is a colourless liquid.
Responda
  • True
  • False

Questão 13

Questão
Boiling point of benzene?
Responda
  • 90 degrees
  • 100 degrees
  • 70 degrees
  • 80 degrees

Questão 14

Questão
Melting point of benzene
Responda
  • 5.5 degrees
  • 10 degrees
  • 3 degrees
  • 2.5 degrees
  • 1 degrees

Questão 15

Questão
Label this drug molecule
Responda
  • Aspirin

Questão 16

Questão
Label this drug molecule
Responda
  • Ibuprofen

Questão 17

Questão
Label this drug molecule
Responda
  • Diazepam

Questão 18

Questão
The halogen atom on an alkylhalide atom is attached to what other atom?
Responda
  • Trigonal sp2 carbon atom
  • Tetrahedral sp carbon atom
  • Trigonal sp3 carbon atom
  • Tetrahedral sp3 carbon atom
  • Trigonal sp carbon atom

Questão 19

Questão
The bond in alkylhalide are non-polar.
Responda
  • True
  • False

Questão 20

Questão
[blank_start]Cl-, Br- and I-[blank_end] are good leaving groups in nucleophilic substitution reactions.
Responda
  • Cl-, Br- and I-

Questão 21

Questão
Alkyl fluorides and fluorocarbons are relatively unstable.
Responda
  • True
  • False

Questão 22

Questão
Although the halogen-alkane bond is polar, they do not have a [blank_start]corresponding electron deficient region.[blank_end]
Responda
  • corresponding electron deficient region.

Questão 23

Questão
Although the halogen-alkane bond is polar, they do not [blank_start]interact strongly with water molecules.[blank_end]
Responda
  • interact strongly with water molecules.

Questão 24

Questão
Although the halogen-alkane bond is polar, they are generally _____
Responda
  • less lipophilic than corresponding non-halogenated molecules
  • more hydrophilic than corresponding non-halogenated molecules
  • more lipophilic than corresponding non-halogenated molecules
  • less hydrophilic than corresponding non-halogenated molecules

Questão 25

Questão
Tick all that is correct about halogens in drugs
Responda
  • Generally make the drug more lipophilic than corresponding non-halogenated molecules
  • Generally make the drug less lipophilic than corresponding non-halogenated molecules
  • Halogenated drugs are less readily metabolised than non-halogenated forms
  • Halogenated drugs are more readily metabolised than non-halogenated forms

Questão 26

Questão
Label this drug molecule
Responda
  • DDT

Questão 27

Questão
Tick all that is correct about DDT
Responda
  • Persistent in the environment
  • Chemically unstable
  • Chemically stable
  • Highly resistant to metabolism
  • Not very resistant to metabolism

Questão 28

Questão
Short-chain alcohols are [blank_start]freely miscible with water.[blank_end]
Responda
  • freely miscible with water.

Questão 29

Questão
The interaction between short-chain alcohols and water can be explained [blank_start]by hydrogen bonding.[blank_end]
Responda
  • by hydrogen bonding.

Questão 30

Questão
A permanent dipole exists in alcohol because of ...
Responda
  • Electronegativity of the hydrogen
  • Electronegativity of the oxygen
  • Electropositive oxygen
  • Electropositive hydrogen

Questão 31

Questão
R-OH dissociates to give [blank_start]R-O-[blank_end]
Responda
  • R-O-

Questão 32

Questão
R-OH accepts a [blank_start]proton to give R-OH2+[blank_end]
Responda
  • proton to give R-OH2+

Questão 33

Questão
Acidity of alcohols depends on the [blank_start]R-group[blank_end]
Responda
  • R-group

Questão 34

Questão
pKa is the [blank_start]negative log[blank_end] of acid dissociation constant
Responda
  • negative log

Questão 35

Questão
Acidity of molecule is increased if it has [blank_start]electron withdrawing group[blank_end] near the -OH group
Responda
  • electron withdrawing group

Questão 36

Questão
Acidity of molecule is also dependent on if the rest of the molecule can [blank_start]stabilise the negative charge.[blank_end]
Responda
  • stabilise the negative charge.

Questão 37

Questão
Phenols are [blank_start]stronger acids[blank_end] than alcohols.
Responda
  • stronger acids

Questão 38

Questão
Phenoxide ions are [blank_start]resonance stabilised.[blank_end]
Responda
  • resonance stabilised.

Questão 39

Questão
What does the -OH functional group do and in what condition?
Responda
  • Release H+ in aqueous solution.

Questão 40

Questão
Relate the O- to the stability of the molecule
Responda
  • Resonance stabilises the negative charge

Questão 41

Questão
Fluorine is strongly electronegative.
Responda
  • True
  • False

Questão 42

Questão
The C-F bond in fluorine is polarised.
Responda
  • True
  • False

Questão 43

Questão
In fluorine, the partially positive charge on the carbon [blank_start]stabilises[blank_end] the negative charge on the hydroxyl group.
Responda
  • stabilises

Questão 44

Questão
Tick all that is correct about the reactivity of phenols.
Responda
  • Readily oxidised
  • Not so readily oxidised
  • Products are colourless because of the conjugated bonds
  • Products are frequently coloured because of the conjugated bonds

Questão 45

Questão
Contribution of alcohols to the properties of drugs: tick all that is correct about hydrogen bonding
Responda
  • Decreases the polarity of molecule
  • Increases the polarity of molecule
  • Adds to water solubility but generally not sufficient alone to ensure full water solubility
  • Ensures full water solubility
  • Involved in drug-target interactions as either a hydrogen bond donor or acceptor

Questão 46

Questão
Label this molecule
Responda
  • Diethylether

Questão 47

Questão
Label this molecule
Responda
  • Morphine

Questão 48

Questão
Tick all this correct about ethers
Responda
  • Do not have hydrogen attached to the oxygen
  • Can be hydrogen bond donors
  • Can be hydrogen bond acceptors
  • Show full water solubility
  • Show partial water solubility
  • Solubility increases with chain length
  • Solubility decreases with chain length

Questão 49

Questão
Ethers can form [blank_start]peroxides in contact with air.[blank_end]
Responda
  • peroxides in contact with air.

Questão 50

Questão
Ethers are generally non-reactive
Responda
  • True
  • False

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