Quiz
Capsules
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Perguntas do quiz (19)
1[blank_start]Hard Gelatin[blank_end] Capsules:
• Drug
• Powder or granulation
[blank_start]Soft Elastic[blank_end] Capsules:
• Liquid
• Semi-solid mass- AHard Gelatin
- BSoft Elastic
2Shells are usually formed from [blank_start]gelatin[blank_end] but may also be made from [blank_start]starch[blank_end] or other substances.
- Hard-shell capsule sizes range from No. [blank_start]5[blank_end] (smallest) to No. [blank_start]000[blank_end] (largest except for veterinary sizes)
- Size No. [blank_start]00[blank_end] is generally the largest size acceptable to patients.- Agelatin
- Bstarch
- C5
- D000
- E00
3• Powder formulations often require adding [blank_start]fillers[blank_end], [blank_start]lubricants[blank_end], and [blank_start]glidants[blank_end] to the active ingredients to facilitate encapsulation.
• The addition of wetting agents to the powder mass is common where the active ingredient is [blank_start]hydrophobic[blank_end]- Afillers
- Blubricants
- Cglidants
- Dhydrophobic
4• [blank_start]Disintegrants[blank_end] also may be included in powder formulations to facilitate [blank_start]deaggregation[blank_end] and dispersal of capsule plugs in the [blank_start]gut[blank_end].
- ADisintegrants
- Bdeaggregation
- Cgut
5[blank_start]Inert sugar beads[blank_end] may be coated with active ingredients and coating compositions that provide extended-release profiles or [blank_start]enteric[blank_end] properties.
- AInert sugar beads
- Benteric
6Alternatively, larger-dose active ingredients themselves may be suitably formed into [blank_start]pellets[blank_end] and then [blank_start]coated[blank_end]
- Apellets
- Bcoated
7Since gelatin is of animal origin and starch is of vegetable origin, capsules made with these materials should be protected from potential sources of [blank_start]microbial contamination[blank_end].
- Amicrobial contamination
8Disadvantages:
• Can’t be used for drugs that [blank_start]solubilize gelatin[blank_end]
• Not suitable for [blank_start]hygroscopic[blank_end] drugs
• Not suitable for [blank_start]deliquescent[blank_end] drugs
• Potential for leaking- Asolubilize gelatin
- Bhygroscopic
- Cdeliquescent
9[blank_start]Deliquescent[blank_end] - becoming liquid or having a tendency to become liquid
- ADeliquescent
10Capsules have fewer excipients than tablets, they contain:
• [blank_start]Drug[blank_end]
• [blank_start]Filler[blank_end]
• [blank_start]Lubricant[blank_end]- ADrug
- BFiller
- CLubricant
11Capsule shell is made of:
• Gelatin
• [blank_start]Water[blank_end]
• [blank_start]Colorants[blank_end]
• Opacifying Agents
• [blank_start]Preservatives[blank_end]
• Miscellaneous ingredients- AWater
- BColorants
- CPreservatives
12• Gelatin is prepared by the [blank_start]thermal denaturation[blank_end] of collagen, isolated from animal skin and bones, with very [blank_start]dilute[blank_end] acid or base (gelatin A or B).
- Athermal denaturation
- Bdilute
13Gelatin contains a large number of [blank_start]glycine[blank_end], [blank_start]proline[blank_end] and 4-[blank_start]hydroxyproline[blank_end] residues
- Aglycine
- Bproline
- Chydroxyproline
14Hard-shell capsules:
• They normally contain between [blank_start]10[blank_end]% and [blank_start]15[blank_end]% water.
• The empty capsules should be stored in tight containers until they are filled.- A10
- B15
15[blank_start]Punch Method[blank_end]:
Procedure for weighing capsules with an electronic balance.
1. Place the balance on a smooth, level surface. Press the tare button and observe the balance set at 000.0.
2. Place a weighing paper and an empty capsule shell of the appropriate size on the balance pan. Re-zero the balance by pressing the tare button. The digital display should read 000.0 After this step, do not touch the tare button again during this weighing operation.
3. Remove the empty capsule shell from the balance pan. The digital display will read a negative value which represents the weight of the capsule shell.
4. For each capsule, punch powder into an empty capsule shell and place it on the balance pan. Add or remove powder to the capsule shell until the digital display shows the desired weight of the capsule powder.- APunch Method
16The uniformity of dosage units can be demonstrated by either of two methods, [blank_start]Content Uniformity[blank_end] or [blank_start]Weight Variation[blank_end]
- AContent Uniformity
- BWeight Variation
17[blank_start]Soft Elastic Capsules[blank_end] can not be prepared in the pharmacy
- ASoft Elastic Capsules
18For soft-gel capsules, a [blank_start]rupture[blank_end] test is conducted in a dissolution apparatus using [blank_start]500[blank_end] mL water and [blank_start]50[blank_end] rpm paddle speed.
If the capsule ruptures within [blank_start]15[blank_end] minutes, the test is passed- Arupture
- B500
- C50
- D15
19[blank_start]Microencapsulation[blank_end]: process or technique by which thin coatings are applied to small particles.
- This is used for very [blank_start]sensitive[blank_end] drugs- AMicroencapsulation
- Bsensitive
Informações
- Descrição
- The student should be able to: The student should have knowledge of the possible content of capsules and the nature of the capsule shells. Describe the advantages and limitations of capsules as dosage forms. Describe the official USP tests required for capsules. Prepare and dispense hard gelatin capsules. Evaluate capsules as a dosage form by performing and analyzing data from official USP tests.
- Autor
- Crystal Yu
- Idioma
- English
- Visualizações
- 127
- Etiquetas
- Avaliação
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