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Quiz

MD16 and 17 Oral dosage forms

Mer Scott 11 perguntas

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Perguntas do quiz (11)

  1. 1Disadvantages of conventional immediate-release:
    1. [blank_start]Sawtooth[blank_end] profile
    2. [blank_start]Repeat[blank_end] administrations needed
    3. Patient [blank_start]compliance[blank_end]
    4. Short [blank_start]half-life[blank_end] drugs
    5. [blank_start]Side effects[blank_end]
    1. ASawtooth
    2. BRepeat
    3. Ccompliance
    4. Dhalf-life
    5. ESide effects
  2. 2Reasons for wanting rapid dissolution:
    • Increase the bioavailability of [blank_start]poorly water soluble[blank_end] drugs (90% of [blank_start]drug candidates[blank_end] are classified as poorly water-soluble)
    • [blank_start]Reduce the time[blank_end] for onset of drug action (eg for analgesics)
    • [blank_start]Dysphagia[blank_end] (dissolve in mouth so patient doesn't need to swallow)
    1. Apoorly water soluble
    2. Bdrug candidates
    3. CReduce the time
    4. DDysphagia
  3. 3If using a co-solvent to increase solubility you must be cautious about precipitation occurring from dilution in the GIT.
    1. AVerdadeiro
    2. BFalso
  4. 4Choice of salt depends on pKa:
    Acidic drugs: pKa of counterion should be 2 pH units [blank_start]above[blank_end] drug pKa.
    Basic drugs: pKa of counterion should be 2 pH units [blank_start]below[blank_end] drug pKa.
    1. Aabove
    2. Bbelow
  5. 5Salts are hygroscopic.
    1. AVerdadeiro
    2. BFalso
  6. 6Cyclodextrin complexes are [blank_start]cyclic[blank_end] sugars and [blank_start]chiral[blank_end] organic molecules. They have a hydrophobic cavity and can carry BSC [blank_start]Class II[blank_end] drugs. They improve drug solubility and [blank_start]stability[blank_end] and can be incorporated into [blank_start]tablets[blank_end].
    1. Acyclic
    2. Bchiral
    3. CClass II
    4. Dstability
    5. Etablets
  7. 7Choose the correct statement.
    1. AVolume of cyclodextrin cavity depends on number of units in the CD ring.
    2. BGamma-cyclodextrin is the most commonly used size.
  8. 8Physical methods to increase dissolution rate:
    1. Nanosizing
    Particle [blank_start]size reduction[blank_end] under one micrometre to increase [blank_start]surface area[blank_end] and therefore dissolution. Reduces [blank_start]food[blank_end] effects. Done by [blank_start]milling[blank_end]. Avoid aggregation by using [blank_start]surfactants or polymers[blank_end].
    2. Polymorphs
    Amorphous form [blank_start]more[blank_end] soluble, but [blank_start]less[blank_end] stable.
    3. Solid dispersions
    Solid solute dispersed in a solid solvent. E.g. [blank_start]Eutectics[blank_end]; increased surface area and sharp [blank_start]lower[blank_end] melting point.
    1. Asize reduction
    2. Bsurface area
    3. Cfood
    4. Dmilling
    5. Esurfactants or polymers
    6. Fmore
    7. Gless
    8. HEutectics
    9. Ilower
  9. 9Pulsatile release is a form of delayed release.
    1. AVerdadeiro
    2. BFalso
  10. 10Delayed release may be useful when drug is [blank_start]acid labile[blank_end](must protect from release in stomach), to prevent [blank_start]gastric irritation[blank_end](eg by NSAIDs), to [blank_start]target delivery[blank_end] to small intestine, or to suit the [blank_start]circadian rhythm[blank_end] of disease state.
    1. Aacid labile
    2. Bgastric irritation
    3. Ctarget delivery
    4. Dcircadian rhythm

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Descrição
PHCY211 (Medicines) Quiz sobre MD16 and 17 Oral dosage forms, criado por Mer Scott em 20-05-2018.
Idioma
English
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