Quiz
Pharmacology Test Prep
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Perguntas do quiz (50)
1The postsynaptic receptors are continuously activated by the transmitter.
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2What causes epilepsy?
- AThe uncontrolled excitation in the nervous system
- BThe uncontrolled excitation in the peripheral nervous system
- CThe uncontrolled inhibition in the central nervous system
- DThe leak of the Na ion channel in neurons
- ENone of the above
3Which of the following sentences about the acetylcholine are correct?
- AIt is an excitatory neurotransmitter in the central nervous system.
- BIn the neuromuscular junction, it is excitatory.
- CIt helps the parasympathetic response of heart.
- DNone of these are correct.
- EIt is an excitatory neurotransmitter in the involuntary skeletal muscle synapse.
4This type of local anesthetic is applied to the subarachnoid space of the spinal cord. The injected needle almost touches filum terminale.
- ASpinal injection
- BIntrathecal injection
- Cepidural injection
5Which is the permanent Na channel blocker?
- ATetrodotoxin
- BSaxitoxin
- CBatrachotoxin
- D4-aminopyridine
6Which of the local anesthetics is consist of an ester?
- ACocaine
- BProcaine
- CLignocaine
- DPrilocaine
- EAmethocaine
- FBupivacaine
7Cocaine is used for clinical usage.
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8What channel do you block to prolong the duration of the action potential?
- AK channel
- BNa channel
- CCa channel
9Although the local anesthetic was introduced in 1846, medical practitioners preferred to use a general anesthetic.
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10Which are the correct G-alpha subunits?
- AGs family
- BGb family
- CGi/o family
- DGq family
- EGr family
- FAll the above
11G protein is used to
- Adetect photons
- Bdetect odor
- Cregulate body mass
- Dregulate blood sugar
- Eregulate the secretion of stomach acid
- Fdetect soundwave
12What are the symptoms of anaphylactic shock?
- AIt is a general allergic reaction.
- Blaryngeal oedema
- Cbronchospasm
- Dhypertension
- Ehypotension
13What is the side effect of salbutamol and what do scientists do to prevent it?
- ATremor
- Bgastrointestinal effect
- Ccardiac effect
- Dno side effect at all
- Euse drugs that are designed to preferentially interact with the subtype of adrenoreceptor found in cardiac muscle
- Fthey don't try anything
- Guse beta 2 type of salbutamol
- Huse beta 1 type of salbutamol
14Why is salbutamol the treatment of asthma? What does it do to our body?
- AIt is not. Epiben is used as the treatment.
- BBecause asthma is a localized overreaction of immune system in the lungs
- CBecause even a large dose of salbutamol will diffuse away
- Dit relaxes cardiac muscle and bronchodilation
- Eit relaxes smooth muscles of lungs and constricts bronchi
- Fincreases the blood pressure
15What is not true about the receptor concentrations in the context of the membrane receptor?
- Athey are free to move in the plane of the membrane
- Bmany of the receptors are not anchored
- Cthey are either free or occupied
- Deven if 3 receptors are active, if those 3 are 1% of the total receptors, there will be no response
16Ka, the equilibrium constant. is (K-1/K+1) and it is an association constant.
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17Which one is the Hill Langmuir equation?
- APr=[A]/Ka+[A]
- BPar=[A]/Ka-[A]
- CPar=[A]/Ka*[A]
- DPr=[A]/Ka-[A]
- Enone of the above
18Which are the correct variation of the Hill Langmuir equation?
- APar=[A]/Ka+[A]
- BPar=K'a [A]/ 1+K'a[A]
- CPar=ca/ 1+ca
- DNone of them are correct
19The dissociation rate constant doesn't have a unit because it is dimensionless.
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20All the occupied receptors are activated.
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21Hill Langmuir equation and Hill equation is the same.
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22If the Ka is 8 microM and the concentration of ibuprofen was 4 microM,
- A1/3
- B1/5
- C1/2
- D1
23What are the accurate descriptions of the Castillo Katx model of receptor activation
- Athe first model to separate agonist binding and receptor gaining step
- Brepresent the conformational change to an active state
- Cthe ratio of the forward to the backward rates
- Dembodies the idea of agonist efficacy
- Eall wrong
- Fall of the above
24Even the tissue reaches the half-maximal response, it doesn't mean that 50% of receptors of the tissue are occupied.
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25The difference between the full agonist and partial agonist comes from their ability to bind with the receptor.
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26Without an agonist, a receptor cannot be active.
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27What are the aminoglycoside antibiotics?
- ANeomycin
- BAtenolol
- CStreptomycin
- DKanamycin
- EAll the above
- FBatracin
28Na-K-ATP-ase pump is an electrogenic pump.
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29What is the main goal of the nervous system?
- ASustaining homeostasis
- BTransfer signal
- CIncrease heart rate and blood pressure
- DMuscle contraction
- EAll the above
30To initiate muscle contraction in the visceral system, you need the enteric system.
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31What are the 3 components of the peripheral nervous system
- Aparasympathetic
- Bsympathetic
- Centeric
- Dvisceral
- Eautonomic
- Fsomatic
- Gsensory
- Hall of them
32Sympathetic ganglia are located close or side of the spinal cord. Preganglionic sympathetic nerves is from the spine and it is short. Postganglionic sympathetic nerves are the opposite.
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33In the peripheral nervous system, axons are called "nerves of nerves fiber".
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34The threshold of an action potential is always at -55 mV.
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35The function of noradrenaline in the sympathetic nervous system depends on its dose.
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36Which is the correct Gaddum equation?
- APar=[A]/Ka(1+[B]/Kb)+[A]
- BPar=[A]Ka(1+[B]Kb)+[A]
- CPbr=[A]/Ka(1+[B]/Kb)+[A]
- DPr=[A]Ka(1+[B]/Kb)+[A]
37When there is no antagonist present, the Gaddum equation is the same as the Hill equation.
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38Which one is the correct Schild equation?
- Ar+1=[B]/Kb
- Br-1=[B]Kb
- Cr-1=[B]/K
- Dr-1=[A]/Ka
- ENone of the above
39What are the components of a local anesthetic?
- Aamide
- Bester
- Caromatic group
- Dside-chain amine
- Enitrogen
- Fall of them
40Is the response of the tissue related to the occupancy of receptors in a direct proportionality?
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41A full agonist is always a full agonist despite the location of the agonist.
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42In the del Castillo-Katz model, even if the receptors are occupied by partial agonists, AR* phase will be shorter than the graph where the receptors are occupied by full agonists
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43What are the types of drug antagonism
- Areversible competitive antagonism
- Bnon-reversible incompetitive antagonism
- Cfunctional antagonism
- Dpharmacokinetic antagonism
- Echemical antagonism
44Phenobarbitone and warfarin are often advised to be taken together.
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45Allosteric antagonists are all reversible.
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46If the calculated t-value is less than or equal to the table value of t, it is considered not to be statistically significant at the significance level.
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47What are the drugs that block the activity of acetylcholinesterase?
- ANeostigmine
- BNeomycin
- CEdrophonium
- DPhysostigmine
- EStreptomycin
48What are the nature of drugs working on the presynaptic and postsynaptic membrane?
- Aaction on transmitter synthesis
- Baction on releasing neurotransmitters
- Caction on inhibiting transmitter release
- Daction on postsynaptically, block ACh receptors
- Eaction on neurotransmitter uptake
49If an antagonist present, the graph of tissue response and drug dose will have a sigmoid curve. When there is an antagonist, the Ka value will be below 1.
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50pA2=-logKb is always right for any antagonist
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Informações
- Descrição
- If you find any of the questions incorrect, please inform me.
- Autor
- Ashley Kim
- Idioma
- English
- Visualizações
- 8
- Etiquetas
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