Genetic Disorders

Question 1

What is a compound heterozygote?

Accepted Answer

Heterogeneous recessive alleles at a particular locus that can cause genetic disease in a heterozygous state

Answer

Two alleles that are heterozygous, but both gene products mimic the wild type allele

Answer

Where one recessive allele causes the mutation of another

Question 2

Autosomal recessive disorders are far more common between consaginous individuals

Answer

true

Question 3

Heterozygotes with autosomal recessive alleles tend to manifest _ strongly than homozygotes

Accepted Answer

Less

Answer

More

Answer

Equally

Question 4

Which of the following relationships describes A & D

Accepted Answer

First cousins once removed

Answer

Second cousins

Answer

Second cousins once removed

Answer

First cousins

Question 5

What is the relationship between A & B

Accepted Answer

First cousins

Answer

Second cousins

Answer

First cousins once removed

Question 6

Name the two factors that lead to Amish Microcelepathy in the Amish population

Accepted Answer

Founder Mutation

Accepted Answer

Co-sanguinous relationships

Answer

Infected Rye

Answer

Insufficient nutrients

Question 7

By English law, how is incest defined?

Accepted Answer

Grandparent-Parent/Grandchild

Accepted Answer

Sibling-Sibling

Accepted Answer

Sibling- Half sibling

Answer

First cousins

Answer

Second cousins

Question 8

What type of relationships would the children of the above parents have?

Accepted Answer

Double first cousins

Answer

Demi-cousins

Answer

Half cousins

Answer

Double second cousins

Question 9

Autosomal dominant mutations have a sex bias

Answer

true

Question 10

What type of disease is being passed on in this pedigree?

Accepted Answer

Autosomal dominant

Answer

Autosomal recessive

Answer

X-Linked recessive

Answer

X-linked dominant

Question 11

Autosomal dominant phenotypes often require environmental factors

Answer

true

Question 12

Which of the sex chromosomes can carry a disorder?

Accepted Answer

X

Accepted Answer

Y

Question 13

Which type of inheritance is shown by the pedigree pictured?

Accepted Answer

Y Linked

Answer

Autosomal dominant

Answer

X-Linked recessive

Answer

Autosomal recessive

Question 14

Chromosome defects most often effect fertility

Answer

true

Question 15

Why would a Y-linked disorder effect fertility?

Accepted Answer

Y chromosome genes most often effect sex organs

Answer

The Y chromosome damages genes for hormones more easily than any other gene

Question 16

Diseased sons with a y-linked disorder must have diseased mothers

Answer

true

Question 17

Which of the following is true of an X-linked recessive disorder?

Accepted Answer

No direct male to male transmission

Accepted Answer

The mother is usually the carrier

Accepted Answer

Effects mainly males

Answer

The father is usually the carrier

Answer

Effects mainly females

Answer

Males cannot be born to unaffected parents

Question 18

A father will an X-linked recessive disease will mean that ALL his daughters are carriers

Answer

true

Question 19

The following pedigree shows which type of inheritence?

Accepted Answer

X-linked dominant

Answer

Y-linked

Answer

X-linked recessive

Question 20

Only females will be effected by an X-linked dominant allele

Answer

true

Question 21

A father with an X-linked dominant will infect all his daughters

Answer

true

Question 22

Of females and males, who are effected more mildly/variably by x-linked dominant disorders?

Accepted Answer

Females

Answer

Males

Answer

Both are effected equally

Question 23

Which of the following is true about Rhett syndrome?

Accepted Answer

It is most likely to occur as you age

Accepted Answer

Caused by an MeCP2 fault

Accepted Answer

Caused by faulty gene expression

Answer

It is most likely to occur in the young

Answer

Caused by haploinsufficiency

Answer

Caused by Pseudodominance

Question 24

Why is Genomic Imprinting a thing?

Accepted Answer

Some genes are selectively expressed from the maternal or paternal allele

Answer

Some genes are more dominant depending which parent it is expressed from

Answer

Maternal genes are more likely to cause disorders than paternal genes

Question 25

Disorders due to genomic imprinting are caused when differential expression is lost

Answer

true

Question 26

Amish microcephaly is an example of what?

Accepted Answer

Autosomal recessive

Answer

Autosomal dominant

Answer

X linked dominant

Answer

X linked recessive

Question 27

Hemimegalencephaly is an example of what?

Accepted Answer

Autosomal dominant

Answer

Autosomal recessive

Answer

X-linked recessive

Answer

Y-linked

Question 28

Non-obstructive spermatogenic failure is an X-linked recessive disease

Answer

true

Question 29

Colour blindness is an example of...

Accepted Answer

X-linked recessive

Answer

Y-linked

Answer

X-linked dominant

Question 30

State some symptoms of CLUB4-mutated X-linked syndrome

Accepted Answer

Microcephaly

Accepted Answer

Small tesetes

Accepted Answer

Impaired speech

Accepted Answer

Impaired gait

Genetic Disorders

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