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Flashcards

Drugs for Stage 2 progress 2

victoriascudamore Inglês 76 flashcards

Flashcards do conjunto (76)

  1. 1CetirizineAnti-histamine- do not cross BBB (ionised at physiological pH)
  2. 2ChlorphenamineAntihistamine for anaphylaxis
  3. 3DiazepamHypnotic - long life
  4. 4TemazepamHypnotic - short life
  5. 5ZopicloneZ-hypnotic
  6. 6HaloperidolFirst generation anti-psychotic
  7. 7Olanzapine/RisperidoneSecond generation anti-psychotic associated with weight gain
  8. 8ClozapineSecond generation anti-psychotic associated with agranulocytosis
  9. 9AmitriptylineTri-cyclic antidepressant
  10. 10FluoxetineSSRI
  11. 11CitalopramSSRI with the strongest affinity for 5-HT
  12. 12VenlafaxineSNRI
  13. 13MirtazepineAtypical antidepressant
  14. 14CyclophosphamideAlylating agent - cancer
  15. 15DoxorubicinCancer drug- Anthracyclines - inhibit Topoisomerase II
  16. 16MethotrexateInhibits DHFR enzyme (preventing folate metabolism)
  17. 17VincristineCancer drug- Binds to tubulin - preventing mitosis
  18. 18ImatinibProtein kinase inhibitor - cancer
  19. 19TamoxifenHormone antagonist of oestrogen - breast cancer
  20. 20CisplatinCauses crosslinking of DNA - cancer
  21. 21DarunavirProtease inhibitor - HAART
  22. 22TenofovirNucleoside Reverse Trnscriptase Inhibitor
  23. 23EfarvirenzDirectly inhibits reverse transcriptase by inhibition
  24. 24AmoxicillinBroad spectrum penicillin - first line against pnuemonia
  25. 25BenzylpenicillinPenicillin often given IV
  26. 26Co-amoxiclavAmoxicillin with B-lactamase
  27. 27Piperacillin with TazobactamPenicillin with B-lactamase - first line against S. Aureus
  28. 28CefotaximeFirst line treatment for meningitis
  29. 29MeropenemUsed in severe sepsis - broad spectrum antibiotic
  30. 30VancomycinAntibiotic reserved for MRSA
  31. 31TrimethoprimFirst line treatment in uncomplicated UTI
  32. 32ChloramphenicolTopical treatment for bacterial conjunctivitis
  33. 33ClarithromycinHypersensitivity alternative for pnuemonia - macrolide
  34. 34ErythromycinHypersensitivity alternative for tonsillitis - macrolide
  35. 35DoxycyclineCompete with tRNA for binding site on ribisome - antibiotic
  36. 36GentamycinUsed in TB treatment - ototoxic
  37. 37ClindamycinActive against penciillin resistant staphylococci - binds to 50S ribosome
  38. 38CiprofloxacinInhibits bacterial DNA gyrase
  39. 39MetronidazoleActive against obligate anaerobic bacteria - antabuse alcohol reaction
  40. 40NitrofurantoinUsed in UTI treatment (not Trimethoprim)
  41. 41RifampicinTB treatment - binds to bacterial RNA polymerase
  42. 42EthambutolInhibit synthesis of mycolic acid - anti-TB
  43. 43PyrazinamideAnti-TB drug with bactericidal activity
  44. 44QuinineActive against P. Falciparum - interrupts detoxification of Haemin
  45. 45ChloroquineUsed in treatment of uncomplicated non-severe malaria
  46. 46Artemisin Combination TherapyBest treatment for P. Falciparum
  47. 47FluconazoleInhibits synthesis of Ergosterol
  48. 48CapsofunginActive against B-1,3-glucan - component of fungal cell wall
  49. 49FluorocystineActive against B-1,3-glucan - component of fungal cell wallI
  50. 50FluorocystineWorks on protein synthesis within the nucleus - anti fungal
  51. 51NystatinBind to ergosterol and create trans-membrane pores - leading to cell membrane collapse
  52. 52AspirinIrreversibly acetylates COX-1
  53. 53Naproxen and IbuprofenCompetitive COX-1 and COX-2 inhibitor
  54. 54CelecoxibInhibitor of COX-2 with less side effects
  55. 55SumatriptanGiven in migraine attack - 5-HT antagonist
  56. 56MorphineMu and Delta opiod agonist
  57. 57DiamorphineVery similar to morphine following deacetylation
  58. 58MethadoneUsed in opiod dependence
  59. 59CodeineWeak opiate
  60. 60TramadolOral opiate used in Chronic Pain
  61. 61LidocaineLocal Anaesthetic
  62. 62AtropinePrevents bradycardia and fluid secretion into respiratory tract - Anaesthetic adjunct
  63. 63Isoflurane and Nitrous OxideInhaled general anaesthetics
  64. 64PropofolTotal general anaesthetic
  65. 65Thiopental SodiumIV General anaesthetic with very high lipid solubility
  66. 66BromocriptineDA receptor agonist - parkinsons
  67. 67SelegilineMAO-B inhibitor
  68. 68DonepezilLong half life Acetylcholine esterase inhibitor used in Dementia treatment
  69. 69FludrocortisoneSynthetic analogue for Aldosterone - used in Addison's Disease
  70. 70RivastigmineShort half life Acetylcholine esterase inhibitor used in Dementia
  71. 71PhenytoinAnti-epileptic targetting VGSCs with very high cerebellar toxicity associated with ataxia
  72. 72Isoniazidnhibits synthesis of mycolic acid [metabolised by NAT2]
  73. 73LamotrigineAnti epileptic targetting VGSCs associated with Steven Johnson syndrome
  74. 74PhenelzineMonoamine Oxidase Inhibitor [Depression]
  75. 75CarbamazepineAnti-epileptic targetting VGSCs - also used in trigeminal neurlagia associated with agranulocytosis
  76. 76SildenafilPhosphodiesterase 5 inhibitor - Erectile Dysfunction

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