PHSI3011 12-1 Comparative Physiology and Thermal #1

Michael Jardine
Quiz by Michael Jardine, updated more than 1 year ago
Michael Jardine
Created by Michael Jardine almost 4 years ago
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PHSI3011 12-1 Comparative physiology and thermal physiology #1

Resource summary

Question 1

Question
GnIH means what?
Answer
  • Gonadotropin Inducing Hormone
  • Gonadotropin Inhibitory Hormone

Question 2

Question
Gonadotropin Inhibitory Hormone (GnIH) first discovered in 2000 in what model?
Answer
  • Birds
  • Mice
  • Fish
  • Salamanders

Question 3

Question
What does GnIH appear to be the “signaller” for in humans?
Answer
  • Stress-related suppression of reproduction
  • Menopause
  • Puberty
  • Pregnancy-induced placentation changes

Question 4

Question
GnIH is also called:
Answer
  • RFamide-Related Peptide-3
  • FRamide-Related Peptide-3
  • RFamide-Related Peptide-1
  • FRamide-Related Peptide-1

Question 5

Question
True or false: GnIH has been found within the NERVOUS SYSTEMS of animals with all major phyla.
Answer
  • True
  • False

Question 6

Question
GnIH is:
Answer
  • Usually released into the portal system, but not in some animals (rats, mice).
  • Released into the portal system, but only in some animals (rats, mice).

Question 7

Question
A major similarity between organisms is that GnIH is always localised in the:
Answer
  • Dorsomedial nucleus of the hypothalamus
  • Dorsomedial nucleus of the hippocampus
  • Dorsal horn of the hypothalamus
  • Dorsal horn of the hippocampus

Question 8

Question
True or false: A major similarity between organisms is that GnIH neurons project to GnRH cells in all mammalian species studied.
Answer
  • True
  • False

Question 9

Question
True or false: A major similarity between organisms is that GnIH neurons project into the neurosecretory zone of the median eminence in all mammalian species studied.
Answer
  • True
  • False

Question 10

Question
Advantages of using LAB AND DOMESTICATED animals as models include: (select all that apply)
Answer
  • Well-adapted to labs
  • Detailed knowledge of genetic background
  • Transgenic manipulation allows specific focus
  • Short generation time (longitudinal studies simple and comprehensive)

Question 11

Question
An example of a “Wild” species used as a model is the Tree shrew. What is it used to model?
Answer
  • PTSD
  • Alzheimer’s
  • Cystic Fibrosis
  • Developmental disorders

Question 12

Question
Alzheimer’s Disease (AD) is characterised by progressive loss of cholinergic neurons projecting from the basal forebrain to which areas: (select all that apply)
Answer
  • Cortical
  • Hippocampal
  • Hypothalamic

Question 13

Question
The two main histopathological hallmarks of Alzheimer’s Disease (AD) are: (select the two that apply)
Answer
  • Extracellular senile plaques containing amyloid-beta (Aβ) which is formed after sequential cleavage of Amyloid Precursor Protein (APP) by the catalytic activity of β-secretases and γ-secretases
  • Intracellular Neurofibrillary Tangles (NFTs)

Question 14

Question
True or false: A disadvantage of using transgenic models of AD is that many are “icon” species and therefore politically unsuitable.
Answer
  • True
  • False

Question 15

Question
Which of the following wild animals could be candidates as AD models? (but aren’t because of reasons) (select all that apply)
Answer
  • Wolverines
  • Dolphins
  • Polar Bears
  • Tasmanian Tigers
  • Tasmanian Devils

Question 16

Question
The best [non-transgenic, anyway] model for Alzheimer's Disease (AD) is the:
Answer
  • Degu (Octodon degus)
  • Guinea pig (Cavia porcellus)
  • Naked mole-rat (Heterocephalus glaber)
  • Domestic dog (Canis familiaris)
  • Fat-tailed dunnart (Sminthopsis crassicaudata)

Question 17

Question
What age do Degus start presenting Alzheimer’s symptoms?
Answer
  • ~3-4 years
  • ~4-5 years
  • ~5-6 years
  • ~6-7 years
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