11493573
Description
Quiz by Michael Jardine, updated more than 1 year ago
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Created by Michael Jardine
over 6 years ago
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Question 1
Question
Atheroma starts as fatty and cellular infiltration of the endothelium. Later becomes larger, [blank_start]__________[blank_end] and [blank_start]__________[blank_end] and may block 80% of the XS of parts of the coronary arteries. (put them in alphabetic order)
Answer
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Calcified
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Fibrosed
Question 2
Question
What’s responsible for the drastically reduced force output in EARLY ischaemic failure?
Answer
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Changes in pH
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Changes in Pi
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Failure of excitation-contaction coupling
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Low ATP
Question 3
Question
True or false: ROS = Reactive Oxygen Species.
Answer
- True
- False
Question 4
Question
Why does early reperfusion cause complete recovery whereas late reperfusion does not?
Answer
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On reperfusion damage mitochondria produce Reactive Oxygen Species (ROS) from O2, which damage membrane and contractile proteins
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Coupled exchanger theory causes Ca2+ overload which activates Ca2+-activated proteases and causes cell damage
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Both of the above
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[none of the above]
Question 5
Question
True or false: ROS can cause damage through protein modification whereby –SH groups are oxidised into –S-S- groups.
Answer
- True
- False
Question 6
Question
True or false: ROS can cause damage through protein modification whereby –S-S- groups are oxidised into –SH groups.
Answer
- True
- False
Question 7
Question
Excess ROS leads to specific mitochondrial damage in which the MPTP opens. MPTP = ??
Answer
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Mitochondrial Permeability Transition Pore
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Modification of Protein Transition Pore
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Mitochondrial Pore Transition Permeability
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Mitochondrial Pore Transition Protein
Question 8
Question
When the MPTP opens, Oxidative phosphorylation [blank_start]__________[blank_end], mitochondrial contents leak out, and the cell will eventually die by necrosis.
Answer
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Stops
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Starts
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Increases
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Decreases
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