AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

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AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

Resource summary

Question 1

Question
Antifungals are:
Answer
  • tetracyclines
  • imidazoles
  • echinocandims
  • triazols

Question 2

Question
Synthetic antifungal drugs are
Answer
  • Nystatin
  • Itraconazole
  • Ketoconazole
  • Fluconazole

Question 3

Question
Antifungal antibiotics are:
Answer
  • Nystatin
  • Tetracycline
  • Gentamycin
  • Amphotericin B

Question 4

Question
Azoles:
Answer
  • are fungistatic
  • inhibit cell wall synthesis
  • inhibit ergosterol synthesis
  • inhibit hepatic CYP450 enzymes

Question 5

Question
lmidazoles are:
Answer
  • Fluconazole and ltraconazole
  • Miconazole and Econazole
  • Given topically
  • Given systematically

Question 6

Question
Ketoconazole is:
Answer
  • the only imidazole that can be given orally
  • used for treatment of bacterial skin infections
  • used topically for cutaneous fungal infections
  • used intravenously for treatment of systemic fungal infections

Question 7

Question
Fluconazole:
Answer
  • it is non- steroidal anti-inflammatory drug
  • is triazole antifungal drug
  • is administered orally or intravenously
  • is excreted mainly unchanged with the urine

Question 8

Question
ADRs of azole antifungals are:
Answer
  • hepatotoxicity
  • endocrine disorders
  • nephrotoxicity
  • nausea, vomiting

Question 9

Question
Point the correct statements for Nystatin:
Answer
  • has fungistatic activity
  • causes gastrointestinal disturbances
  • is effective against Trichomonas vaginalis
  • is effective against Candida species

Question 10

Question
ADRs of Amphoteracin B are:
Answer
  • renal impairment
  • hypokalemia
  • hypotension
  • liver impairment

Question 11

Question
Antiviral drugs act by following mechanisms
Answer
  • inhibition of viral “uncoating”
  • inhibition of viral DNA or RNA synthesis
  • inhibition of viral proteases
  • inhibition of viral penetration into the cell

Question 12

Question
Point out the correct statements for Aciclovir:
Answer
  • it inhibits viral DNA polymerase
  • it is used for “treatment of herpesvirus infections
  • it inhibits neuraminidase enzyme
  • can be applied topically, orally or intravenously

Question 13

Question
ADRs of Aciclovir are:
Answer
  • hepatotoxicity
  • renal impairment
  • local irritation
  • encephalopathy (at high i.v. doses)

Question 14

Question
Drugs for prevention and treatment of flu are:
Answer
  • Aciclovir (Zovirax)
  • Amantadin (Symmetrel)
  • Rimantadin (Flumadine)
  • Oseltamivir (Tamiflu)

Question 15

Question
Mechanism of action of Oseltamivir (Tamiflu) is
Answer
  • interference with the function of the viral M2 protein
  • inhibition of specific neuraminidase enzyme
  • inhibition of reverse transcriptases
  • inhibition of proteases

Question 16

Question
For Amantadine and Rimantadine is true:
Answer
  • resistance can develop rapidly
  • they are effective against both type A and type B influenza
  • they are effective against type A influenza viruses
  • they interfere with the function of the viral M2 protein and block uncoating of the Virus particles

Question 17

Question
Mechanisms of action of drugs for treatment of HIV infection are:
Answer
  • inhibition of reverse transcriptase
  • inhibition of HIV protease
  • inhibition of HIV entry into the host cell
  • inhibition of the insertion of proviral DNA. into the host cell genome

Question 18

Question
Point out the correct statements for Zidovudin;
Answer
  • it blocks HIV reverse transcriptase
  • it blocks HIV protease
  • it is a nucleoside analogue
  • it can cause anemia and neutropenia

Question 19

Question
ADRS of Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are:
Answer
  • peripheral neuropathy
  • pancreatitis
  • polymyositis
  • glaucoma

Question 20

Question
HIV protease inhibitors are:
Answer
  • Zidovudin
  • Indinavir
  • Ritonavir
  • Aciclovir

Question 21

Question
For HIV protease inhibitors is true:
Answer
  • protease inhibition prevents maturation of the viral particles
  • they are enzyme inducers
  • they are enzyme inhibitors
  • they are combined with other antiretroviral drugs in the treatment of HIV infection

Question 22

Question
ADRs of HIV protease inhibitors are:
Answer
  • hyperlipidaemia
  • insulin resistance and hyperglycaemia
  • hypoglycaemia
  • fat redistribution

Question 23

Question
Inhibitor of both hepatitis B virus (HBV) and HIV reverse transcriptases is:
Answer
  • Zidovudin
  • Lamivudin
  • Aciclovir
  • lndinavir

Question 24

Question
Protease inhibitor for treatment of chronic hepatitis C infection is:
Answer
  • Aciclovir
  • Telaprevir
  • Zidovudin
  • Oseltamivir

Question 25

Question
Antimycobacterial drugs are:
Answer
  • Rifampicin
  • Isoniazid
  • Ethambutol
  • Amoxicillin

Question 26

Question
Rifampicin (Rifampin):
Answer
  • is bactericidal antibiotic with antimycobacterial activity
  • is antiviral drug
  • is broad spectrum antibiotic
  • is enzyme inducer

Question 27

Question
Mechanism of action of Rifampicin (Rifampin) is
Answer
  • inhibition of cell wall synthesis
  • inhibition of 50 S ribosomal subunit
  • inhibition of DNA-dependent RNA polymerase
  • increased cell membrane permeability

Question 28

Question
ADRs of Rifampicin (Rifampin) are:
Answer
  • heart failure
  • orange-red color of urine and other secretions
  • hepatotoxicity
  • hypoglycaemia

Question 29

Question
Point out the correct statements for lsoniazid:
Answer
  • inhibits the synthesis of essential for mycobacteria mycolic acid
  • it is metabolized by, acetylation
  • it is specific for treatment of M. Tuberculosis
  • it is active against broad spectrum of bacteria

Question 30

Question
ADRs of lsoniazld are:
Answer
  • renal impairment
  • peripheral neuropathy
  • convulsions
  • hepatitis

Question 31

Question
lsoniazid-induced peripheral neuropathy can be avoided by:
Answer
  • supplementation with vitamin B1
  • supplementation with vitamin A
  • supplementation with vitamin B6
  • supplementation with vitamin B12

Question 32

Question
ADRs of Pyrazinamide are:
Answer
  • hepatotoxicity
  • arrhythmia
  • hyperuricaemia
  • hypoglycaemia

Question 33

Question
Ethambutol:
Answer
  • is bacteriostatic antimycobacterial drug
  • may cause liver failure
  • may cause optic neuritis
  • inhibits synthesis of the mycobacterial cell wall
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