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MICR223 Innate Immunity
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Questions in this quiz (28)
1What is involved in distinguishing between dangerous and non dangerous pathogens?
- AInflammasome
- BNLRs
- CBoth
- DNeither
2What is a PAMP?
- APathogen association membrane proteins
- BProtein assisted molecular pathway
- CPathogen associated molecular patterns
- DPathogen antigen model patterns
3What does a PRR do?
- ATransport proteins around the cell
- BProduces cytokines directly
- CAffects gene transcription
- DRecognises pathogen patterns
- EStarts a signalling pathway
4Which of the following is incorrect about PAMPS
- AFlagellin is the PAMP for flagellated bacteria
- BLipolysaccharides is the PAMP for Gram -ve bacteria
- CPeptidoglycan is also a PAMP for Gram -ve bacteria
- DZymosan is the PAMP for fungi
- EssRNA a PAMP for viral infection
5What makes an ideal PAMP?
- ASomething heavy in lipids
- BSomething that is fundemental to the cells function
- CToxins
- DSelf antigen.
6What makes an ideal PAMP?
- ASomething heavy in lipids
- BSomething that is fundemental to the cells function
- CToxins
- DSelf antigen.
7Why must we have a signal for pathogen vs self as well as for dangerous vs non dangerous?
- ABecause if we react to self antigen our immune system attacks our own bodies
- BBecause many of the organisms in our body are commensals and killing them could lead to opportunistic infections
- CBecause two signals allow are more controlled reaction
- DSo that if you get one signal and not the other only a small or no response occurs. Minimises damage.
8Why must we have a signal for pathogen vs self as well as for dangerous vs non dangerous?
- ABecause if we react to self antigen our immune system attacks our own bodies
- BBecause many of the organisms in our body are commensals and killing them could lead to opportunistic infections
- CBecause two signals allow are more controlled reaction
- DSo that if you get one signal and not the other only a small or no response occurs. Minimises damage.
9Which are incorrect?
- AC-type lectin receptors detect fungal antigen
- BRIG-1 like Receptors recognise protozoan antigen
- CToll like receptors recognise bacterial antigen
- DNOD- like receptors recognise only bacterial antigen
10What receptors recognise Candida? and what does it lead to?
- ADectin-1 Th17 adaptive immune response
- BDectin-2 Th17 adaptive immune response
- CMannose receptors Th17 adaptive immune response
11What does mincle recognise?
- ABacillius subtilis
- BMalassezia spp and trehalose dimycolate from M.tuberculosis.
- CClostridium spp C.difficile, C.tetani and C.botulinum
- DProtozoa
12What is the outcome of TLR signalling?
- AInflammatory cytokines
- BT cell stimulating cytokines
- CAnti inflammatory cytokines
13Which is incorrect?
- ARLRs signal outcomes are inflammatory cytokines esp IFNs
- BCLRs Signal outcomes are Tcell stimulating cytokines esp IL-17
- CNLRs signal outcomes are Inflammatory cytokines IL-2
14Where do you find NOD like receptors?
- AIn a vesicle
- BIn the cytosol
- CIn the membrane
- DIn the lymph node
15Which is correct?
- ANOD1 recognises G -ve bacteria
- BNOD2 recognises all bacteria
- CNOD proteins recognise danger and viruses
- DThere is more NOD in epithelial cells
- ENOD is also in APCs
- FNOD2 recognises only gram +ve bacteria
- GNOD1 recognises fungi
- HNod proteins recognise danger and protozoa
16Which of these are acute inflammatory cytokines?
- AIL-1, IL-7, IL-17
- BIL-1, IL-8, IL-18
- CIL-1, IL-2, IL17
- DIL-1, TFNbeta, IL-3
17What is the role of NFKB?
- ATo compete for binding of CD28 with CD80.
- BA link between PRR and transcription.
- CA mediator of acute inflammation
- DA anti inflammatory cytokine
18What type of inflammasome responds to all bacterial stimuli and is the one we learnt?
- ANLRP3
- BNLRC4
- CNLRP1
- DAIM2
19What is a danger signal?
- AA signal from a co-stimulatory receptor that is only expressed when in danger
- BA signal that indicates cell death e.g. crystal salts.
20What are these proteins part of? Cardinal, Asc and caspase?
- AThe inflammasome
- BMHCI
- CMHCII
- DTCR
21Why is the inflammasome a target for medicine?
- ABecause many auto-immune disease involve excessive inflammation
- BBecause it causes poor immune response
22What are adjuvants?
- AKilled pathogens used in vaccines.
- BAgents that boost the immune response by acting as danger signals
23What is gout?
- AAn auto immune disease?
- BThe build up of uric acid crystals
- CExcessive inflammation due to signal 2 being activated
- DIL-1Ralpha used as an antagonist to treat
24What is the name of this disorder? IL-1 and IL-18 are produced, mice with this deficiency for NLRP3 have poor inflammasome development. IL-18 is used in gut function to mediate gut repair
- AInflammatory bowl disease
- BAddisons disease
- CGout
25What is an antigen?
- ASomething a Tcells and Bcell receptors recognise
- BBroken down macromolecules specific to foreign organisms
- CSomething that directly stimulates Tcells to become different subsets
- DSomething that indicates self antigen
26What is an immunogen and an epitote?
- AImmunogen - antigen that initiates immune system
Epitote - part of the antigen that binds to TCR/BCR - BImmunogen - part of the antigen that binds to TCR/BCR
Epitote - antigen that initiates immune system
- AImmunogen - antigen that initiates immune system
27How many genes does the human genome have?
- A15000
- B25000
- C17000
- D27000
28How many different Tcell and Bcell receptors do we have as humans?
- A25000000
- B3500000
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- Quiz on MICR223 Innate Immunity, created by ruby.white94 on 03/10/2013.
- Author
- ruby.white94
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- English
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