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Drug molecules - properties and actions & functional groups

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Masters Degree Pharmacy (Case 1 - Introduction) Quiz on Drug molecules - properties and actions & functional groups, created by Alyssa B on 02/01/2016.
Alyssa B
Quiz by Alyssa B, updated more than 1 year ago
Alyssa B
Created by Alyssa B over 8 years ago
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Resource summary

Question 1

Question
What shape is a sp3 hybridised C?
Answer
  • Tetrahedral
  • Trigonal planar
  • Linear

Question 2

Question
What shape is a sp2 hybridised C
Answer
  • Tetrahedral
  • Trigonal planar
  • Linear

Question 3

Question
What shape is a sp hybridised C
Answer
  • Tetrahedral
  • Trigonal planar
  • Linear

Question 4

Question
Alkanes are unsaturated hydrocarbons. True or false?
Answer
  • True
  • False

Question 5

Question
Alkenes are [blank_start]more[blank_end] reactive than alkanes because the delocalised electrons make them susceptible to attack by electrophiles.
Answer
  • more

Question 6

Question
Alkenes undergo [blank_start]electrophilic addition reactions[blank_end]
Answer
  • electrophilic addition reactions

Question 7

Question
Alkynes are [blank_start]less[blank_end] reactive than alkenes.
Answer
  • less

Question 8

Question
Alkynes undergo
Answer
  • Substitution reactions
  • Electrophilic addition reactions but at a quicker rate than alkenes
  • Nucleophilic substitution reactions
  • Electrophilic addition reactions but at a slower rate than alkenes

Question 9

Question
Arenes are [blank_start]highly unsaturated[blank_end] and [blank_start]cyclic.[blank_end]
Answer
  • highly unsaturated
  • cyclic.

Question 10

Question
Arenas do not behave like alkenes and alkynes because they [blank_start]do not decolourise bromine water.[blank_end]
Answer
  • do not decolourise bromine water.

Question 11

Question
What type of molecule is benzene?
Answer
  • Trigonal planar
  • Planar
  • Linear
  • Tetrahedral

Question 12

Question
Benzene is a colourless liquid.
Answer
  • True
  • False

Question 13

Question
Boiling point of benzene?
Answer
  • 90 degrees
  • 100 degrees
  • 70 degrees
  • 80 degrees

Question 14

Question
Melting point of benzene
Answer
  • 5.5 degrees
  • 10 degrees
  • 3 degrees
  • 2.5 degrees
  • 1 degrees

Question 15

Question
Label this drug molecule
Image:
f02f83e3-abf9-4486-a4f5-62aa1996f881 (image/png)
Answer
  • Aspirin

Question 16

Question
Label this drug molecule
Image:
dba13c14-641f-4b63-84df-60c4f5a39e4d (image/png)
Answer
  • Ibuprofen

Question 17

Question
Label this drug molecule
Image:
bc01fa4a-4524-4639-8834-57397258fed3 (image/png)
Answer
  • Diazepam

Question 18

Question
The halogen atom on an alkylhalide atom is attached to what other atom?
Answer
  • Trigonal sp2 carbon atom
  • Tetrahedral sp carbon atom
  • Trigonal sp3 carbon atom
  • Tetrahedral sp3 carbon atom
  • Trigonal sp carbon atom

Question 19

Question
The bond in alkylhalide are non-polar.
Answer
  • True
  • False

Question 20

Question
[blank_start]Cl-, Br- and I-[blank_end] are good leaving groups in nucleophilic substitution reactions.
Answer
  • Cl-, Br- and I-

Question 21

Question
Alkyl fluorides and fluorocarbons are relatively unstable.
Answer
  • True
  • False

Question 22

Question
Although the halogen-alkane bond is polar, they do not have a [blank_start]corresponding electron deficient region.[blank_end]
Answer
  • corresponding electron deficient region.

Question 23

Question
Although the halogen-alkane bond is polar, they do not [blank_start]interact strongly with water molecules.[blank_end]
Answer
  • interact strongly with water molecules.

Question 24

Question
Although the halogen-alkane bond is polar, they are generally _____
Answer
  • less lipophilic than corresponding non-halogenated molecules
  • more hydrophilic than corresponding non-halogenated molecules
  • more lipophilic than corresponding non-halogenated molecules
  • less hydrophilic than corresponding non-halogenated molecules

Question 25

Question
Tick all that is correct about halogens in drugs
Answer
  • Generally make the drug more lipophilic than corresponding non-halogenated molecules
  • Generally make the drug less lipophilic than corresponding non-halogenated molecules
  • Halogenated drugs are less readily metabolised than non-halogenated forms
  • Halogenated drugs are more readily metabolised than non-halogenated forms

Question 26

Question
Label this drug molecule
Image:
ce346e1f-ba73-4706-87c0-6a1c395d2e7e (image/png)
Answer
  • DDT

Question 27

Question
Tick all that is correct about DDT
Answer
  • Persistent in the environment
  • Chemically unstable
  • Chemically stable
  • Highly resistant to metabolism
  • Not very resistant to metabolism

Question 28

Question
Short-chain alcohols are [blank_start]freely miscible with water.[blank_end]
Answer
  • freely miscible with water.

Question 29

Question
The interaction between short-chain alcohols and water can be explained [blank_start]by hydrogen bonding.[blank_end]
Answer
  • by hydrogen bonding.

Question 30

Question
A permanent dipole exists in alcohol because of ...
Answer
  • Electronegativity of the hydrogen
  • Electronegativity of the oxygen
  • Electropositive oxygen
  • Electropositive hydrogen

Question 31

Question
R-OH dissociates to give [blank_start]R-O-[blank_end]
Answer
  • R-O-

Question 32

Question
R-OH accepts a [blank_start]proton to give R-OH2+[blank_end]
Answer
  • proton to give R-OH2+

Question 33

Question
Acidity of alcohols depends on the [blank_start]R-group[blank_end]
Answer
  • R-group

Question 34

Question
pKa is the [blank_start]negative log[blank_end] of acid dissociation constant
Answer
  • negative log

Question 35

Question
Acidity of molecule is increased if it has [blank_start]electron withdrawing group[blank_end] near the -OH group
Answer
  • electron withdrawing group

Question 36

Question
Acidity of molecule is also dependent on if the rest of the molecule can [blank_start]stabilise the negative charge.[blank_end]
Answer
  • stabilise the negative charge.

Question 37

Question
Phenols are [blank_start]stronger acids[blank_end] than alcohols.
Answer
  • stronger acids

Question 38

Question
Phenoxide ions are [blank_start]resonance stabilised.[blank_end]
Answer
  • resonance stabilised.

Question 39

Question
What does the -OH functional group do and in what condition?
Image:
06845255-602b-4865-a69f-52c990865255 (image/png)
Answer
  • Release H+ in aqueous solution.

Question 40

Question
Relate the O- to the stability of the molecule
Image:
f6342ec3-496c-4a8b-b569-059b636d77e3 (image/png)
Answer
  • Resonance stabilises the negative charge

Question 41

Question
Fluorine is strongly electronegative.
Answer
  • True
  • False

Question 42

Question
The C-F bond in fluorine is polarised.
Answer
  • True
  • False

Question 43

Question
In fluorine, the partially positive charge on the carbon [blank_start]stabilises[blank_end] the negative charge on the hydroxyl group.
Answer
  • stabilises

Question 44

Question
Tick all that is correct about the reactivity of phenols.
Answer
  • Readily oxidised
  • Not so readily oxidised
  • Products are colourless because of the conjugated bonds
  • Products are frequently coloured because of the conjugated bonds

Question 45

Question
Contribution of alcohols to the properties of drugs: tick all that is correct about hydrogen bonding
Answer
  • Decreases the polarity of molecule
  • Increases the polarity of molecule
  • Adds to water solubility but generally not sufficient alone to ensure full water solubility
  • Ensures full water solubility
  • Involved in drug-target interactions as either a hydrogen bond donor or acceptor

Question 46

Question
Label this molecule
Image:
fc50889a-6589-42c4-9787-904bab8a200c (image/png)
Answer
  • Diethylether

Question 47

Question
Label this molecule
Image:
0db82b25-799e-4923-8c57-f15660e76135 (image/png)
Answer
  • Morphine

Question 48

Question
Tick all this correct about ethers
Answer
  • Do not have hydrogen attached to the oxygen
  • Can be hydrogen bond donors
  • Can be hydrogen bond acceptors
  • Show full water solubility
  • Show partial water solubility
  • Solubility increases with chain length
  • Solubility decreases with chain length

Question 49

Question
Ethers can form [blank_start]peroxides in contact with air.[blank_end]
Answer
  • peroxides in contact with air.

Question 50

Question
Ethers are generally non-reactive
Answer
  • True
  • False
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