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Macrocytic Anaemia

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Haematology and Anatomy (Red Blood Cells) Quiz on Macrocytic Anaemia, created by gina_evans0312 on 08/01/2014.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
What defines Non-Megaloblastic Anaemia?
Answer
  • No large nucleus & excess cell membrane- no DNA involvement
  • Large nucleus, effected DNA

Question 2

Question
In Melagoblasic Anaemia, other blood cells are likely to be affected
Answer
  • True
  • False

Question 3

Question
Liver disease and alcohol cause what type of anaemia?p
Answer
  • Melagoblastic Macrocytic
  • Non-Megaloblastic Macrocytic

Question 4

Question
Which of the following is not a cause of Melagoblastic Anaemia?
Answer
  • HIV treatment
  • B12 deficiency
  • Iron deficiency
  • Folate deficiency

Question 5

Question
Pancytopaenia- a reduction of all three blood components
Answer
  • True
  • False

Question 6

Question
Why is pancytopaenia a symptom of Megaloblastic anaemia?
Answer
  • Cells apoptose due to DNA synthesis failure
  • Cells cannot be produced due to crowded bone marrow
  • Cells die because of insufficient folate

Question 7

Question
Megaloblastic anaemia leads to a shorter cell lifespan
Answer
  • True
  • False

Question 8

Question
Megaloblastic anaemia has an Inc MCV but Dec RDW
Answer
  • True
  • False

Question 9

Question
Erythrocyte precursors with retarded nuclear maturation
Answer
  • Megaloblasts
  • Oval Macrocytes
  • RBC fragments

Question 10

Question
Oval macrocytes -> larger reiculocytes ->
Answer
  • Larger R.B.C's
  • Smaller R.B.C's
  • Fragmented R.B.C's

Question 11

Question
In M.M.A, cells are less fragile and cannot be broken down, so they accumulate in the blood
Answer
  • True
  • False

Question 12

Question
Which of the following are symptoms of M.M.A?
Answer
  • Hypersegmented neutrophils
  • Giant Metamelanocytes

Question 13

Question
Which of the following are results of EXTREME B12/Folate deficiency?
Answer
  • Dementia
  • Neuropathy
  • Jaundice

Question 14

Question
What is the role of B12?
Answer
  • A Co-Enzyme
  • A substrate for globin production
  • A neurotransmitter

Question 15

Question
B12 is only synthesised in micro-organisms
Answer
  • True
  • False

Question 16

Question
Where is B12 stored?
Answer
  • The liver
  • The kidneys
  • The spleen

Question 17

Question
GI diseases, tapeworm and a lack of intrinsic factor all cause what?
Answer
  • Malapsorption of B12
  • Failure of B12 metabolism
  • Transcabalmin II deficiency

Question 18

Question
Transcabalmin II (TCII) deficiency can be tested for
Answer
  • True
  • False

Question 19

Question
Folate is very sensitive to cooking and will degrade easily
Answer
  • True
  • False

Question 20

Question
How long will the liver stores of folate last?
Answer
  • 3 weeks
  • 3 months
  • 3 years

Question 21

Question
Pregnancy and chronic haemolytic conditions cause what?
Answer
  • Inc Folate requirement
  • Inadequate folate intake
  • Folate malabsorption

Question 22

Question
Folate deficiency can be drug induced
Answer
  • True
  • False

Question 23

Question
Folate is vital for rapidly dividing cells
Answer
  • True
  • False

Question 24

Question
Folate deficiency can cause....
Answer
  • Spinal cord degeneration
  • Abnormal skin development
  • Everything starts tasting of fish
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