34378499
Description
Quiz by ACAPUN INSTITUTE, updated more than 1 year ago
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Created by ACAPUN INSTITUTE
over 2 years ago
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|
Question 1
Question
Which of the following drugs is useful in treating dermatologic manifestations of an allergic response?
Answer
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a. Diazepam
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b. Atropine
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c. Hexylresorcinol
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d. Chlorpheniramine
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e. Phenoxybenzamine
Question 2
Question
Cimetidine is used therapeutically to
Answer
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a. Stimulate respiration
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b. Protect against anaphylaxis
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c. Decrease gastric acid secretion
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d. Hasten excretion of barbiturates
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e. Dilate smooth muscles of the bronchioles
Question 3
Question
Gastric acid secretion has been shown to be most effectively reduced with the use of
Answer
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a. Adrenal steroids
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b. Anticholinergic drugs
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c. Serotonin antagonists
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d. H1-histamine receptor antagonists
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e. H2-histamine receptor antagonists
Question 4
Question
Drug-mediated inhibition of H2-histamine receptors is most useful in treating
Answer
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a. Asthma
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b. Anaphylaxis
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c. Contact dermatitis
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d. Gastric hyperacidity
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e. Localized allergic reactions
Question 5
Question
Which of the following antihistamines is most commonly used as preoperative medication?
Answer
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a. Meclizine
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b. Cyclizine
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c. Promethazine
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d. Dimenhydrinate
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e. Chlorpheniramine
Question 6
Question
Use of diphenhydramine (Benadryl) in controlling the symptoms of parkinsonism is based upon which of the following effects?
Answer
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a. Anticholinergic
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b. Local anesthetic
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c. Adrenergic-blocking
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d. CNS depressant on the midbrain
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e. Stimulant to dopaminergic nerves in the basal ganglia
Question 7
Question
The mechanism of action of H1 antihistamines is
Answer
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a. MAO enzyme inhibition
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b. competitive antagonism
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c. physiologic antagonism
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d. noncompetitive antagonism
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e. inhibition of release of bound histamine
Question 8
Question
Which of the following drugs is often used to treat trigeminal neuralgia?
Answer
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a. clonazepam
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b. carbamazepine
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c. acetazolamine
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d. succinylcholine
Question 9
Question
The use of epinephrine for local hemostasis during surgery might result in
Answer
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a. hypoglycemia
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b. cardiac arrthymia
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c. an acute asthma attack
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d. a drastic drop in blood pressure
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e. any of the above
Question 10
Question
The highest risk associated with use of oral contraceptives is
Answer
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a. hepatic necrosis
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b. permanent sterility
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c. cancer of the breast
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d. cancer of the uterus
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e. thromboembolic disorders
Question 11
Question
Factors common to all forms of drug abuse include EXCEPT
Answer
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a. miosis
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b. tolerance
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c. physical dependence
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d. psychological dependence
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e. any of the above
Question 12
Question
Alcoholic euphoria results from
Answer
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a. increased activity of the cerebellum
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b. increased activity of the cerebral areas
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c. increased activity of the spinal synapses
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d. decreased activity of the medullary centers
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e. removal of inhibitory activity of the cortex
Question 13
Question
Sulfonyl ureas cause insulin secretion by
Answer
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a. adrenergic simulation
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b. cholinergic stimulation
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c. direct stimulation of pancreatic beta cells
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d. dependent of glucosa
Question 14
Question
If a patient requiring an extraction reports that he is on dicoumarol therapy, the laboratory test most valuable in evaluating the surgical risk is
Answer
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a. clotting time
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b. bleeding time
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c. sedimentation rate
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d. complete blood cell count
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e. plasma prothrombin time
Question 15
Question
A drug has a half-life of 4 hours. If 2 gms are given every 4 hrs what will be the amount in gms in the body immediately after the third dose?
Answer
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a. 1.5
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b. 2.0
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c. 3.5
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d. 4.0
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e. 6.0
Question 16
Question
Which of the following combinations represents acceptable agonistantagonist pairs in antidotal therapy?
Answer
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a. morphine-naloxone
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b. dicoumarol-protamine
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c. warfarin-phenylbutazone
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d. carbon monoxide-carbon dioxide
Question 17
Question
The various insulin preparations useful in the treatment of diabetes mellitus differ primarily in
Answer
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a. locus of action
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b. mechanism of action
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c. mode of transformation
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d. onset and duration of action
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e. none of the above
Question 18
Question
Displacement of a drug from protein binding sites is expected to increase the
Answer
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a. drug effect observed
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b. duration of drug effect
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c. dose required for a given effect
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d. none of the above
Question 19
Question
In an addisonian crisis (hypoaldosteronism) resulting from stress from a minor dental procedure, the patient should be treated immediately with
Answer
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a. 0.5 ml norepinephrine
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b. 5 mg. prednisolone acetate
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c. 1% triamcinolone acetonide
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d. 0.5 ml, 1:1000 epinephrine
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e. 2 ml (100 mg) hydrocortisone hemisuccinate
Question 20
Question
Drug A inhibits the biotransformation of Drug B. The duration of action of drug B in the presence of drug A will usually be
Answer
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a. shortened
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b. prolonged
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c. unchanged
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d. equal
Question 21
Question
In which of the following groups of drugs is there the most consistency in chemical structure?
Answer
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a. diuretics
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b. antiepileptics
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c. local anesthetics
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d. general anesthetics
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e. nonbarbiturate sedatives
Question 22
Question
Cimetidine is administered to
Answer
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a. aid in sleeping
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b. relieve asthma
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c. inhibit gastric secretion
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d. relieve cold and flu symptoms
Question 23
Question
Which of the following anticancer drugs can be classified as an antimetabolite?
Answer
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a. cisplatin
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b. lomustine
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c. vincristine
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d. methotrexate
Question 24
Question
Which of the following hormones acts to elevate blood concentration of ionic calcium?
Answer
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a. glucagon
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b. parathyroid
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c. aldosterone
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d. thyrotropin
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e. thyrocalcitonin
Question 25
Question
Disorientation, confusion, and hallucinations resulting from an overdose of scopolamine are most efficaciously treated by administering
Answer
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a. atropine
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b. levodopa
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c. acetylcholine
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d. physostigmine
Question 26
Question
Developed hyporeactivity to a drug is
Answer
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a. tolerance
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b. antagonism
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c. detoxification
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d. desensitization
Question 27
Question
Absorption of a drug from the intramuscular site of administration may be slowed by
a. excercise
b. vasoconstriction
c. the presence of congestive heart failure
d. administering the drug as an insoluble complex
Answer
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1. a and b
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2. b only
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3. b, c, and d
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4. b and d
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5. all of the above
Question 28
Question
Salicylism includes which of the following?
a. nausea
b. tinnitus
c. vomiting
d. gastrointestinal bleeding
Answer
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1. a, b, and c
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2. a, b, and d
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3. a and c only
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4. b, c, and d
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5. all of the above
Question 29
Question
Which of the following are important criteria for the adequate clinical evaluation of a new drug?
a. comparison with a placebo
b. evaluation of side effects
c. utilization of control groups
d. comparison with a standard drug
e. double blind experimental design
Answer
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1. a, b, c, and d
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2. a, b, d, and e
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3. a, c, d, and e
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4. b, c, and e
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5. b, d and e only
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6. all of the above
Question 30
Question
Each of the following agents has a long duration of action due to the presence of liver generated active metabolites EXCEPT
Answer
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a. diazepam
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b. oxazepam
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c. flurazepam
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d. chlordiazepoxide
Question 31
Question
Each of the following statements relates to the general aspects of toxicology EXCEPT
Answer
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a. most drugs exert a single action
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b. toxicity is both time and dose dependent
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c. toxicity can be due to overdosage of a drug
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d. symptoms of toxicity can be anything ranging from nausea to death
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e. for some drugs, even a minimal concentration can be harmful
Question 32
Question
The central actions of ethyl alcohol are not synergistic with which of the following?
Answer
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a. diazepam
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b. meperidine
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c. pentobarbital
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d. chlorpromazine
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e. methylphenidate
Question 33
Question
A heroin dependent patient should not be given nalbuphine (Nubain) for pain because
Answer
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a. it has no analgesic properties
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b. it may produce respiratory depression
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c. as a mixed agonist-antagonist, it can elicit withdrawal symptoms
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d. the high abuse potential of nalbuphine may add to the patient's problems
Question 34
Question
All of the following methods of drug biotransformation are classified as synthetic except:
Answer
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a. N-alkylation
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b. O-dealkylation
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c. sulfate conjugation
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d. glucuronide conjugation
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