Quiz
Pharmacology VIII
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Questions in this quiz (28)
1Atropine and propantheline exert their effects on peripheral structures by
- Aa. preventing release of acetylcholine
- Bb. preventing synthesis of acetylcholine
- Cc. enhancing destruction of acetylcholine
- Dd. competeing with acetylcholine for receptor sites
- Ee. producing physiologic effects opposite to those of acetylcholine
2Neostigmine produces its effect by physostigmine. These differ from the insecticides and nerve gases listed below in that they are reversible and can be used clinically; the latter are irreversible
- Aa. depressing acetylcholinesterase release
- Bb. inhibiting acetylcholinesterase activity
- Cc. increasing the rate of acetylcholine synthesis
- Dd. acting like acetylcholine at ganglionic sites
- Ee. increasing the amount of acetylcholine released from nerve terminals
3Organophosphate insecticides and nerve gases inhibit the action of which of the following enzymes?
- Aa. adenylate cyclase
- Bb. monoamine oxidase
- Cc. phosphodiesterase
- Dd. acetylcholinesterase
- Ee. carbonic anhydrase
4Drugs which are additive with or potentiate the effects of acetylcholine include
(a) methacholine
(b) scopolamine
(c) pralidoxime
(d) neostigmine
(e) pilocarpine- A1. (a), (b), and (c)
- B2. (a), (c), and (d)
- C3. (a), (d) and (e)
- D4. (b), (d), and (e)
- E5. (c), (d) and (e)
5Which of the following drugs is best to administer after poisoning by an organophosphate cholinesterase inhibitor?
- Aa. atropine
- Bb. phenytoin
- Cc. pralidoxime
- Dd. propantheline
- Ee. phenobarbital
6Which of the following compounds is a ganglionic blocking agent?
- Aa. curarine
- Bb. edrophonium
- Cc. mecamylamine
- Dd. succinylcholine
- Ee. gallamine triethodide
7Which of the following acts by antagonizing cholinesterase?
- Aa. atropine
- Bb. muscarine
- Cc. neostigmine
- Dd. pilocarpine
- Ee. acetylcholine
8When neostigmine is administered before acetylcholine, the action of acetylcholine will be
- Aa. blocked
- Bb. enhanced and prolonged
- Cc. less intense and of shorter duration
- Dd. none of the above. The action of acetylcholine is not affected by neostigmine
9Neostigmine can stimulate denervated skeletal muscle because it
- Aa. is a congener of acetylcholine
- Bb. is a competitive blocking agent
- Cc. has no effect on acetylcholinesterase
- Dd. is more potent than diisopropylfluorophosphate
- Ee. is capable of acting directly on the end-plate
10Which of the following is used to prevent laryngospasm?
- Aa. atropine
- Bb. epinephrine
- Cc. diazepam (Valium)
- Dd. neostigmine (Prostigmine)
- Ee. succinylcholine (Anectine)
11In treating xerostomia, which of the following might be prescribed?
- Aa. atropine
- Bb. ephedrine
- Cc. neostigmine
- Dd. scopolamine
- Ee. mecamylamine
12Which of the following drugs is most likely to dry secretions in the oral cavity?
- Aa. diazepam
- Bb. promethazine
- Cc. physostigmine
- Dd. propantheline
- Ee. diphenhydramine
13The most useful drug to induce salivation is one which has properties that are
- Aa. adrenergic
- Bb. cholinergic
- Cc. ganglionic blocking
- Dd. adrenergic blocking
- Ee. cholinergic blocking
14Drugs that are commonly used in the control of excessive salivation include
(a) meprobamate
(b) atropine
(c) methantheline
(d) codeine
(e) chlorpromazine- A1. (a) and (b) only
- B2. (a), (b), and (c)
- C3. (b) and (c) only
- D4. (b), (c), and (d)
- E5. (d) and (e)
15Drugs that are commonly used in the control of excessive salivation include
(a) meprobamate
(b) atropine
(c) methantheline
(d) codeine
(e) chlorpromazine- A1. (a) and (b) only
- B2. (a), (b), and (c)
- C3. (b) and (c) only
- D4. (b), (c), and (d)
- E5. (d) and (e)
16Tachycardia in a patient administered with atropine or scopolamine results from
- Aa. release of adrenal catecholamines
- Bb. blockade of vagus nerve activity
- Cc. blockade of the nicotinic cholinergic receptor
- Dd. stimulation of the alpha adrenergic receptor
- Ee. stimulation of the beta adrenergic receptor
17All of the following are possible effects of cholinomimetic drugs except
- Aa. mydriasis
- Bb. bradycardia
- Cc. increased peristalsis
- Dd. stimulation of sweat glands
- Ee. increased secretion by bronchial glands
18A paralyzing dose of succinylcholine initially elicits
- Aa. CNS stimulation
- Bb. CNS depression
- Cc. decreased salivation
- Dd. muscle fasiculation
- Ee. extrapyramidal reactions
19Based on its known mechanism and sites of action, scopolamine should theoretically be useful in
(a) treatment of peptic ulcer
(b) providing euphoria and amnesia prior to surgery
(c) relieving bronchoconstriction
(d) relieving some of the symptoms of Parkinson disease
(e) visualization of the retina- A1. (a), (b), (d) and (e)
- B2. (a), (b), and (e) only
- C3. (a),and (c)
- D4. (b) and (e) only
- E5. All of the above
20Symptoms of poisoning by an organophosphate insecticide include all of the following except:
- Aa. skeletal muscle fasiculation
- Bb. excessive salivation
- Cc. bronchoconstriction
- Dd. hot, dry skin
- Ee. diarrhea
21All of the following symptoms are associated with neostigmine poisoning except
- Aa. diarrhea
- Bb. salivation
- Cc. convulsions
- Dd. bonchiolar constriction
- Ee. skeletal muscle paralysis
22Symptoms of atropine poisoning in man include
(a) decreased intraocular pressure
(b) burning dry mouth
(c) nausea, vomiting and diarrhea
(d) hyperthermia
(e) orthostatic hypotension- A1. (a) and (c)
- B2. (b) and (d)
- C3. (b), (d), and (e)
- D4. (d) and (e)
- E5. All of the above
23The most likely signs or symptoms of overdosage with atropine are
- Aa. CNS excitation and tachycardia
- Bb. intestinal cramps and diarrhea
- Cd. ptyalism and increased sweating
- De. constriction of the pupils and blurring of vision
24Disorientation, confusion and hallucinations resulting from an overdose of scopolamine are most efficaciuosly treated by administering
- Aa. atropine
- Bb. levodopa
- Cc. acetylcholine
- Dd. physostigmine
25The immediate cause of death from irreversible cholinesterase inhibitors is
- Aa. shock
- Bb. convulsion
- Cc. cardiac arrhythmia
- Dd. respiratory paralysis
- Ee. dehydration from vomiting and diarrhea
26Each of the following is a symptom of cholinergic crisis except
- Aa. bradycardia
- Bb. lacrimation
- Cc. vasoconstriction
- Dd. extreme salivation
- Ee. weakness of voluntary muscles
27Succinylcholine is a short-acting neuromuscular junction blocking agent useful for providing a brief paralysis to aid in intubating patients. It is short-acting because
- Aa. it is subject to rapid metabolism in the liver
- Bb. it rapidly redistributes away from the NMJ
- Cc. it is subject to inactivation by plasma esterases
- Dd. it undergoes rapid inactivation in the GI tract
28Atropine-like drugs are classed as
- Aa. anti-adrenergic
- Bb. cholinomimetic
- Cc. sympatholytic
- Dd. anti-cholinergic
- Ee. sympathomimetic
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- Praxis Tests: Pharmacology Quiz on Pharmacology VIII, created by ACAPUN INSTITUTE on 08/11/2021.
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- ACAPUN INSTITUTE
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