34379550
Description
Quiz by ACAPUN INSTITUTE, updated more than 1 year ago
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Created by ACAPUN INSTITUTE
over 2 years ago
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Question 1
Question
Atropine and propantheline exert their effects on peripheral structures by
Answer
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a. preventing release of acetylcholine
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b. preventing synthesis of acetylcholine
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c. enhancing destruction of acetylcholine
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d. competeing with acetylcholine for receptor sites
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e. producing physiologic effects opposite to those of acetylcholine
Question 2
Question
Neostigmine produces its effect by physostigmine. These differ from the insecticides and nerve gases listed below in that they are reversible and can be used clinically; the latter are irreversible
Answer
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a. depressing acetylcholinesterase release
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b. inhibiting acetylcholinesterase activity
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c. increasing the rate of acetylcholine synthesis
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d. acting like acetylcholine at ganglionic sites
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e. increasing the amount of acetylcholine released from nerve terminals
Question 3
Question
Organophosphate insecticides and nerve gases inhibit the action of which of the following enzymes?
Answer
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a. adenylate cyclase
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b. monoamine oxidase
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c. phosphodiesterase
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d. acetylcholinesterase
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e. carbonic anhydrase
Question 4
Question
Drugs which are additive with or potentiate the effects of acetylcholine include
(a) methacholine
(b) scopolamine
(c) pralidoxime
(d) neostigmine
(e) pilocarpine
Answer
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1. (a), (b), and (c)
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2. (a), (c), and (d)
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3. (a), (d) and (e)
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4. (b), (d), and (e)
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5. (c), (d) and (e)
Question 5
Question
Which of the following drugs is best to administer after poisoning by an organophosphate cholinesterase inhibitor?
Answer
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a. atropine
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b. phenytoin
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c. pralidoxime
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d. propantheline
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e. phenobarbital
Question 6
Question
Which of the following compounds is a ganglionic blocking agent?
Answer
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a. curarine
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b. edrophonium
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c. mecamylamine
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d. succinylcholine
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e. gallamine triethodide
Question 7
Question
Which of the following acts by antagonizing cholinesterase?
Answer
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a. atropine
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b. muscarine
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c. neostigmine
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d. pilocarpine
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e. acetylcholine
Question 8
Question
When neostigmine is administered before acetylcholine, the action of acetylcholine will be
Answer
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a. blocked
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b. enhanced and prolonged
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c. less intense and of shorter duration
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d. none of the above. The action of acetylcholine is not affected by neostigmine
Question 9
Question
Neostigmine can stimulate denervated skeletal muscle because it
Answer
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a. is a congener of acetylcholine
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b. is a competitive blocking agent
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c. has no effect on acetylcholinesterase
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d. is more potent than diisopropylfluorophosphate
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e. is capable of acting directly on the end-plate
Question 10
Question
Which of the following is used to prevent laryngospasm?
Answer
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a. atropine
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b. epinephrine
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c. diazepam (Valium)
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d. neostigmine (Prostigmine)
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e. succinylcholine (Anectine)
Question 11
Question
In treating xerostomia, which of the following might be prescribed?
Answer
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a. atropine
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b. ephedrine
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c. neostigmine
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d. scopolamine
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e. mecamylamine
Question 12
Question
Which of the following drugs is most likely to dry secretions in the oral cavity?
Answer
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a. diazepam
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b. promethazine
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c. physostigmine
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d. propantheline
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e. diphenhydramine
Question 13
Question
The most useful drug to induce salivation is one which has properties that are
Answer
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a. adrenergic
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b. cholinergic
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c. ganglionic blocking
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d. adrenergic blocking
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e. cholinergic blocking
Question 14
Question
Drugs that are commonly used in the control of excessive salivation include
(a) meprobamate
(b) atropine
(c) methantheline
(d) codeine
(e) chlorpromazine
Answer
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1. (a) and (b) only
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2. (a), (b), and (c)
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3. (b) and (c) only
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4. (b), (c), and (d)
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5. (d) and (e)
Question 15
Question
Drugs that are commonly used in the control of excessive salivation include
(a) meprobamate
(b) atropine
(c) methantheline
(d) codeine
(e) chlorpromazine
Answer
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1. (a) and (b) only
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2. (a), (b), and (c)
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3. (b) and (c) only
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4. (b), (c), and (d)
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5. (d) and (e)
Question 16
Question
Tachycardia in a patient administered with atropine or scopolamine results from
Answer
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a. release of adrenal catecholamines
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b. blockade of vagus nerve activity
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c. blockade of the nicotinic cholinergic receptor
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d. stimulation of the alpha adrenergic receptor
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e. stimulation of the beta adrenergic receptor
Question 17
Question
All of the following are possible effects of cholinomimetic drugs except
Answer
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a. mydriasis
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b. bradycardia
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c. increased peristalsis
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d. stimulation of sweat glands
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e. increased secretion by bronchial glands
Question 18
Question
A paralyzing dose of succinylcholine initially elicits
Answer
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a. CNS stimulation
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b. CNS depression
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c. decreased salivation
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d. muscle fasiculation
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e. extrapyramidal reactions
Question 19
Question
Based on its known mechanism and sites of action, scopolamine should theoretically be useful in
(a) treatment of peptic ulcer
(b) providing euphoria and amnesia prior to surgery
(c) relieving bronchoconstriction
(d) relieving some of the symptoms of Parkinson disease
(e) visualization of the retina
Answer
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1. (a), (b), (d) and (e)
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2. (a), (b), and (e) only
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3. (a),and (c)
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4. (b) and (e) only
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5. All of the above
Question 20
Question
Symptoms of poisoning by an organophosphate insecticide include all of the following except:
Answer
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a. skeletal muscle fasiculation
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b. excessive salivation
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c. bronchoconstriction
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d. hot, dry skin
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e. diarrhea
Question 21
Question
All of the following symptoms are associated with neostigmine poisoning except
Answer
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a. diarrhea
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b. salivation
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c. convulsions
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d. bonchiolar constriction
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e. skeletal muscle paralysis
Question 22
Question
Symptoms of atropine poisoning in man include
(a) decreased intraocular pressure
(b) burning dry mouth
(c) nausea, vomiting and diarrhea
(d) hyperthermia
(e) orthostatic hypotension
Answer
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1. (a) and (c)
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2. (b) and (d)
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3. (b), (d), and (e)
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4. (d) and (e)
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5. All of the above
Question 23
Question
The most likely signs or symptoms of overdosage with atropine are
Answer
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a. CNS excitation and tachycardia
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b. intestinal cramps and diarrhea
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d. ptyalism and increased sweating
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e. constriction of the pupils and blurring of vision
Question 24
Question
Disorientation, confusion and hallucinations resulting from an overdose of scopolamine are most efficaciuosly treated by administering
Answer
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a. atropine
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b. levodopa
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c. acetylcholine
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d. physostigmine
Question 25
Question
The immediate cause of death from irreversible cholinesterase inhibitors is
Answer
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a. shock
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b. convulsion
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c. cardiac arrhythmia
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d. respiratory paralysis
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e. dehydration from vomiting and diarrhea
Question 26
Question
Each of the following is a symptom of cholinergic crisis except
Answer
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a. bradycardia
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b. lacrimation
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c. vasoconstriction
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d. extreme salivation
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e. weakness of voluntary muscles
Question 27
Question
Succinylcholine is a short-acting neuromuscular junction blocking agent useful for providing a brief paralysis to aid in intubating patients. It is short-acting because
Answer
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a. it is subject to rapid metabolism in the liver
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b. it rapidly redistributes away from the NMJ
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c. it is subject to inactivation by plasma esterases
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d. it undergoes rapid inactivation in the GI tract
Question 28
Question
Atropine-like drugs are classed as
Answer
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a. anti-adrenergic
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b. cholinomimetic
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c. sympatholytic
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d. anti-cholinergic
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e. sympathomimetic
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