Karteikarten

S.08.01

Zoe Fernyhough Englisch 15 Karten

Karten in diesem Stapel (15)

1Mb functionMuscle cells
transports O2 from cytosol to mit.
2Hb functioncarries O2 in RBCs, from lungs to tissues
carries H+ and CO2 from tissues to lungs
3how much of Erythrocytes are Hb?30%, increasing O2 solubility in blood by 98%
4RBC energyno mitochondria/ other orgnelles so..
Anaerobic glycolysis, PPP,
5Conjugated protein = apoprotein + cofactor (for Hb and Mb)Mb: apoMb + 1 Heme group
Hb: 2 alpha, 2 beta chains + 4 Hemes
6Hb structureEach Hb: 4 subunits: 1 alpha or beta, attached to a Heme
Tetrahedral arrangement
7Ferric v FerrousFerric: Fe 3+ (oxidized) (hemin)
Ferrous: Fe 2+ (reduced) (heme)
8Heme structurePlanar, aromatic, Fe in middle attached to 4 Ns, mostly nonpolar
93 interactions within Heme moleculenonpolar pocket for heme
covalent bond: heme and iron
ion pairing: COO- w/ + charged AA
10Where does O2 bind in Hb and Mb?Fe in 6th coordination spot
H bonds to His
11Oxygenation vs. OxidationOxygenation: Heme binds O2
Oxidation: Heme --> Hemin + O2. reactive
12metHb/ methemoglobinemiametHb build up, (low O2 transport) treatable w/ reducing agents
13Mb Structure75% is alpha helices (8)
similar to globin folds
nonpolar AAs interior
14Heme binding in Mbnonpolar side chains
15—

Beschreibung: Karteikarten am S.08.01, erstellt von Zoe Fernyhough am 11/10/2016.
Erstellt von: Zoe Fernyhough
Aufrufe: 1
Bewertung