Extracellular Matrix Molecules

Extracellular Matrix Molecules

1. Glycoproteins

   • Laminin
     • Structure: cross-shaped heterotrimer
       • Organizes ECM by interacting with cells and ECM molecules
   • Collagen
     • Structure: triple helix
       • Can form fibers OR networks
       • Provides stiffness or tensile strength
   • Fibronectin
     • Structure: homodimer w/ three domains
       • Organizes ECM by interacting with cells and ECM molecules
         • Can form Fibers
   • Elastin
     • Forms crosslinked networks
       • Allows tissues to stretch and contract

2. Proteoglycans

   • GAGs: chain of repeating disaccharides, long (>10 sugars), linear (unbranched), highly negatively charged