H.M

H.M

1. Scoville and Milner 1957

   • fell off bike
     • 7 years old
     • epileptic seizure
       • 10 years old
     • prevent normal life
       • 27 years old
   • Scoville
     • esperimental surgery
       • removal of medial temporal lobe
         • hippocampus
       • stop seizure
   • Amnesia
     • partial retrograde
     • anterograde
   • memory
     • x explicit
       • semantic
       • episodic
     • can implicit
       • procedural memory
   • working memory
     • normal conversation
       • forget immediately
   • Personality
     • unchanged
     • no general intellectual impairment

2. Localization

   • hippocampus and areas
     • convert memory of experiences
       • from STM to LTM
   • retain memory before
     • medial and hippocampus
       • x permanent store
         • organise memories
           • store elsewhere
       • FOCR memory
         • cortical area
           • long term knowledge storage
             • how to use in everyday
       • procedural memories
         • x stored in hippocampus
       • deficit in certain memory types
         • multiple memory systems
           • supported by distinct brain regions
   • memory
     • much complex
       • hippocampus important
         • new memory storage
           • not the only structure

3. Corkin et al. 1997

   • MRI scan
     • precise pic-analyse
       • brain damage extent
         • parts of temporal lobes
           • hippocampus
             • on both sides
               • critical STM to LTM
                 • neurotransmitter pathway
           • amygdala