Zusammenfassung der Ressource
Paraventricular Leukomalacia
- Oligodendrocytes devoloping
- OL progenitor, marker: NG2
- Pre-OL: O4 and NG2
- Immature OL; O4 and O1
- Mature OL: O1 and MBP
- Vulnerability of OLs
- high ATP consumption
- hydrogen peroxide production
- Low Gluthione (antioxidant)
- CP-AMPARs?
- sphingolipids
- ceramide
- DR5 and CD95 clusters
- OL's signalling
- Organization
- Form Na+ clusters on axons
- Signalling
- Receive excitatory input
- Experimental models
- Rodent OL are postnatal!
- CNS hypoxiaischemia
- Immune resonse: administrate bacterial lipopolysaccharides
- Diagnosis
- MRI, but not in unstable babies
- Ultrasonography!
- Prevention/treatments
- Careful monitor PCO2 and other gases
- Types and consequences
- Focal vs. Diffuse
- Focal
- Microscopic
- Macroscopic
Anmerkungen:
- About or less than 5% of babies with PVL
- Cystic or non-cystic