GPCR signalling and structure

Beschreibung

Undergraduate BMS 301 Mindmap am GPCR signalling and structure, erstellt von Kristi Brogden am 17/11/2014.
Kristi Brogden
Mindmap von Kristi Brogden, aktualisiert more than 1 year ago
Kristi Brogden
Erstellt von Kristi Brogden vor etwa 11 Jahre
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Zusammenfassung der Ressource

GPCR signalling and structure
  1. Structure
    1. Provides clues to complexity of signalling
      1. And hope for development of new theraputics
      2. Comparison of four GPCR structures
      3. GPCR engineering
        1. Yields high resolution structural insights into receptor function
          1. Why did it take 15+ years to crystalize and solve a GPCR structure?
          2. Rhodopsin vs other GPCR's
          3. GPCR structure predicts
            1. Complexity in function
              1. Agonist biased signalling
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