Zusammenfassung der Ressource
GPCR signalling and structure
- Structure
- Provides clues
to complexity
of signalling
- And hope for
development of
new theraputics
- Comparison
of four GPCR
structures
- GPCR
engineering
- Yields high resolution
structural insights into
receptor function
- Why did it take 15+
years to crystalize and
solve a GPCR structure?
- Rhodopsin
vs other
GPCR's
- GPCR structure predicts
- Complexity in function
- Agonist biased signalling