Inflamation

Inflamation

1. Vascular Phase

   • Immediate short moment of vasoconstriction
     • Vasodialation of arterioles and venules
       • Increased vascular permeablity
         • protein rich exudate into extravascular space
           • reduction in capillary osmotic pressure
           • Increase interstitial osmotic presure
             • swelling, pain and loss off function
       • Increased capillary blood flow
         • Increased heat and redness
         • Cellular Phase
           • Delivery of leukocytes to damaged tissue area via arteriole (majority being neutorphils)
             • Migration to site
               • Adhesion to capillary wall
                 • Transmigration into interstitial fluid
                   • Arrival to damaged cells
                     • Accomplished through chemotaxis
                       • movement as a result of chemical gradients
                     • Leukocyte activation
                       • Chemicals produced by injured cells activate phyagocytosis of injured cell
                 • Caused by complementary adhesion molecules

2. Cell Damage