Lymph Node APCs release cytokines

Lymph Node APCs release cytokines

1. TGF-Beta + IL-6

   • CD4 (To) ----> Th-17 Cell
     • Th-17 translates ROR-Gamma-T which leads to secretion of IL-17
       • Inducing Neutrophils and Inflammation

2. Macro --> IL-12 NK --> IFN-Gamma

   • CD4(To) ----> Th-1 Cell
     • Th-1 translates T-Bet which leads to secretion of IL-2 + IFN-Gamma + TNF-Alpha
       • Activating Macrophages to kill Intra-cellular microbes (cell-mediated)
       • Regulation"

3. IL-4

   • CD4(To) ----> Th-2 Cell
     • Th-2 translates GATA-3 which leads to secretion IL-4 + IL-5
       • IL-4 Stimulates IgE Proliferation IL-5 Stimulates Eosiophils to kill with their enzymes
       • When bound to same antigen, they help B-Cells make anti-body for Extra-cellular Parasites (humoral)
       • "Cross

4. TGF-Beta

   • CD4(To) ----> TREG Cell
     • TREG cell markers are CD-4, CD-25, and FOX-3-P
     • TREG [TF: FOX-3-P] secretion of TGF-Beta + IL-10
       • When bound to the same APC, they suppress Effector T-Cell Signal 2 (CD80/86)
         • TGF-Beta leads to Proliferation IL-10 inactivates the APc bind inhibiting CD80/86