Cell Injury

Cell Injury

1. EMFGDh (hurGDh)

2. causes * PPTH:Dr..iii

3. mechanism*: pdf=bdf= 《bdDdf 》 -b:PRH - d:Top -Dd:RCR - f of E: l-OMg -f of fi:RBC+pip

4. pathological : 1-ATP ^Depletion 2-DMP 3-⬆ca + 4-##toxic compounds h2o2

   • ca⬆i: 1-d*phosphlipids 2-d*ATP 3-protease✂c.p 4- endonuclease ▶NAD

5. patterns of cell injury

   • lethal:cell death
     • apoptosis ✒ =sdfsصدف however is - CRP in body *sometimes failure ot prd underine some disease -active p single c+intact +no inflammatory
       • physiological :-embryogenesis
       • pathological :- tumer *liver cells in hepatitis
     • necrosis:- DT due be.. limp * *always pathological +groups of C *inflammatory repair is common
       • coagulative N:- 1-c all dead butT.architecture 3faint⬅proteins.C ,TS by fibrosis 5-most organs and common
       • liquefactive:-N 1-brain 2-T liquefied و heal➡ by glial R
       • caseous :- 1-cheesy ..casein 2-D T is granular and structureless 3-tuberculosis
       • Gangrene:-N with putrefaction of T⬅ c.bacteria. -T appear black ⬅dis from D.HG.
       • fibrinoid.N:- smw.cf سمو كف -NT ➡fibrin in staining. P _Arterioles in case of Vasculitis malignant HT
       • fat N:- 1-traumatic:D trauma to AD.T▶ extracellular release fat as brast 2-enzymatic :-✂✂of fat ⬅lipase E with form -chalky w.spot like acute pancreatitis
   • sublethal : " cellular degeneration": *its a morphological cell changes *reversible *but irrversible d if j persistent
     • hydropic d: - c be pale +swollen etiology :- **H.CP** patho:- a..dmit f ↪Na by water ▶swelling
     • fatty d: vacuolation of C⬅ %lipid Droplets patho:-suppress LME▶ to%intacellular fat *liver⬅HAD

6. Ionizing. R:- 1-electro-: xو gamma ray 2-particulate:-A.B.N

   • mode: Ractive Radical :-Hو oh وh2o2 و O2then interact with m.Lو DNA -D d:- 1-cell death or mitosis 2-just reapair 3-p changein genotype *effect on t: dose radiosenstivity
     • early:-BM, Gut.epithlium, vascular .endothlial Damage
       • late:-V.insufficiency :-thrombosis,v.thicking ⬅intimal prolife 2-atrophy ⬅V.i, c.c.loss 3-genome mutation :⬆ neoplastic .transformation