Quiz
Pathology
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Questions in this quiz (18)
1Permanent tissues (cardiac muscle, skeletal muscle and nerves) cannot undergo hyperplasia, as they do not have stem cells
- ATrue
- BFalse
2Metaplasia is an adaptive change from one ___________________________ cell type to ________________________________-
- Adifferentiated
- Banother differentiated cell type
3Dysplasia is recognized by the alteration in the ___________________________ of cells and is still ______________________
- Asize, shape and arangement
- Breversible
4All of the following are key drivers of cell injury except?
- ALoss of ATP
- BIncrease in cytoplasmic calcium
- Cdecrease in cytoplasmic calcium
- DGeneration of Reactive oxygen species
5All of the following are conditions where there is hypoxia without ischemia
- AHigh altitude
- Bdecreased ventilation
- Cdecreased Oxygen transfer (ex. emphysema)
- DPolycythemia
- ECO poisoning
6Loss of ATP in cell injury leads to all of the following except
- AImpairs oxidative phosphorylation
- BLoss of function of Na/K ATPase pump
- CCalcium influx thereby increasing intracytoplasmic calcium
- DIncrease in pH causing clumping of chromatin
- Edecreased protein synthesis due to ribosomal dysfunction and swelling
7All of the following result due to increased cytoplasmic calcium in cell injury except?
- AIncreased calcium activates phospholipase, protease, endonuclease and ATPase etc
- BIt also activates mitochondrial permeability transition pore which results in loss of membrane potential of mitochondria further limiting oxidative phosphorylation
- CLipid peroxidation and membrane damage
- DNone of the above
8All of the following about ROS is correct except
- AMost potent ROS is O2-
- BH2O2 can act distant from site of production and is the intermediary of hydroxyl radical
- CPeroxynitrite (ONOO-) damages lipids proteins and DNA
9Which of the following are the morphological changes that are seen in REVERSIBLE cell injury?
- ACell swelling
- BCytoplasmic eosinophilia
- CPlasma membrane blebbing
- DChromatin clumping and redistribution due to decreased pH
- EAll of the above
- FNone of the above
10The morphologic hallmark of cell death (irreversible cell injury) is loss of nucleus
- ATrue
- BFalse
11Coagulative necrosis in which tissue becomes a dry, opaque, eosinophilic mass containing the outlines of anucleated cells, resulting from the denaturation of proteins following hypoxia - is seen in all tissues except brain
- ATrue
- BFalse
12Pancreatitis exhibits 2 forms of necrosis they are 1____________________ and 2____________________________
- ALiquefactive
- BFat
13Caseous necrosis usually caused by mycobacterial or fungal infections
- ATrue
- BFalse
14The difference between dry and wet gangrene is that dry gangrene is associated with infection whereas the wet gangrene is not
- ATrue
- BFalse
15Resumption of blood supply and oxygenation to ischemic tissue may lead to further injury and tissue destruction
- ATrue
- BFalse
16Necrosis happens to a group of cells which leads to inflammation whereas apoptosis affects single cells marked by shrinkage of the cell, condensation of chromatin, formation of cytoplasmic blebs and fragmentation of the cell into membrane bound apoptotic bodies that are eliminated by phagocytosis
- ATrue
- BFalse
17Regarding apoptosis
- AAnti apoptotic proteins are BCL-2,BCL-XR, MCL1 - keep the Mitochondrial outer membrane impermeable by preventing the leakage of cytochrome c and other death-inducing proteins into the cytosol
- BPro-apoptotic BAX and BAK upon activation oligomerizes within the outer mitochondrial protein and promote mitochondrial permeability by forming a channel in the outer membrane that allows leakage of cytochrome c from the intermembranous space
- Capoptosis is mediated by caspases - intrinsicpathway by inactivation of BCL-2
- DExtrinsic pathway via FasL-Fas death receptors
- EAll of the above are true
- F1,2 and 4 are true
- G3,4 are true
- HNone of the above
18Atrophy is a result of decrease in stress which results in decrease in size and or volume of cell mass
- ATrue
- BFalse
Information
- Description
- questions on cell injury and inflammation
- Author
- ivenkat
- Language
- English
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- 102
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