Transmission/plasticity influencers

Transmission/plasticity influencers

1. Temperature (Hedrick and Waters, 2011)

   • At 24–26°C
     • Intrinsic membrane properties that increase
       • Resting input resistance
       • membrane time constant
       • , curvature of the I–V relationship
   • no difference in resting membrane potential
   • 36-37C

2. Ca2+

   • increase extracellular
   • Increase intracellular
     • U-shaped relationship for LTD
     • Excitotoxicity

3. Age of the animals

   • Few LTD studies in adults
   • Age-related pathologies
     • Alzheimers

4. Pathology

   • FXS
     • mGluR1/5
     • Enhanced LTD
     • Severe mental retardation
   • Epilepsy
   • Autism
     • Interestingly, there are no freaking studies on synaptic plasticity in savant syndrome! (at least as far as I could find on pubmed.)
     • Structural plasticity

5. Glia cells

   • Stroke
   • Transmitter uptake and release

6. Pre-synaptic

   • RRP
   • Calcium
   • Retrograde transmission

7. Post-synaptic

   • Receptors
   • Channels
   • Morphology
   • Second messengers