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Drug interactions

Therapeutic index of an interacting drug

cyclosporine – an immunosuppressant widely used to prevent organ transplant rejection,

digoxin – a sodium ⁄ potassium ATPase pump inhibitor which was among the first drugs to show effectiveness in the treatment of congestive heart failure

lithium carbonate – with diverse actions in the central nervous system and still a mainstay in the treatment of bipolar disorder,

methotrexate – a folic acid synthesis inhibitor used in the treatment of various cancers and more recently in slowing the joint destruction of rheumatoid arthritis,

phenytoin – a sodium channel blocker in the central nervous system with potent anticonvulsant activity,

theophylline- a phosphodiesterase inhibitor and adenosine receptor antagonist employed frequently in severe asthma, and

warfarin – an inhibitor of vitamin K-dependent clotting factors and the prototype